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Federación Mexicana de Ginecología y Obstetricia, A.C.

2013, Number 12

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Ginecol Obstet Mex 2013; 81 (12)

Anti-mullerian hormone serum levels in women with and without uterine fibroids

Carranza-Lira S, Bustamante-Mendoza JA, Leaños-Miranda A, Campos-Galicia I, Estrada-Moscoso I, Chan-Verdugo R, Ramos-Godínez MP, Moncada-Claudio G, Peña-Torres ML

Language: Spanish
References: 36
Page: 700-705
PDF size: 332.70 Kb.


ABSTRACT

Background: The etiology of uterine leiomyomatosis is multifactorial and it is unknown if a relation between anti- Müllerian hormone (hormona anti-mülleriana) and uterine leiomyomatosis exists.
Objective: To determine the differences of hormona antimülleriana levels in women with and without uterine leiomyomatosis.
Methods: 60 women were studied (30 with and 30 without uterine leiomyomatosis). The diagnosis was confirmed by histopathology. Both groups were paired by age and in all them serum levels of hormona antimülleriana were measured using ELISA, also estradiol and progesterone serum levels were determined. hormona anti-mülleriana-RII immunohistochemistry was done in healthy myometrium and in leiomyomas.
Results: The mean age between the groups didn’t show statistical difference (41.8 ± 5.6 years vs. 41.4 ± 5.7 years). Also no differences were found in weight, height and body mass index. Serum levels of hormona antimülleriana were lower in those with leiomyomatosis [0.21 (0-10.4) ng/ml vs. 1.83 (0-6.38) ng/ml, p < 0.005]. No statistical differences were found in estradiol and progesterone serum levels between the groups. The hormona antimülleriana receptor was no expressed neither in the healthy myometrium nor in the leiomyomas.
Conclusions: Women with leiomyomatosis had lower hormona antimülleriana levels. More studies are needed to determine if a relation exists between hormona antimülleriana and uterine leiomyomas.


REFERENCES

  1. Vigier B, Picard JY, Tran D, Legeai L, Josso N. Production of anti-müllerian hormone: another homology between Sertoli and granulose cells. Endocrinology 1984;114:1315-1320.

  2. Cohen-Haguenauer O, Picard JY, Mattei MG, Serero S, Nguyen VC, De Tand MF, et al. Mapping of the gene for antimüllerian hormone to the short arm of human chromosome 19. Cytogenet Cell Gener 1987;44:2-6.

  3. Jaffe RB. Disorders of sexual development. In: Yen SSC, Jaffe RB, Barbieri RL. Eds. Reproductive endocrinology. Physiology, pathophysiology and clinical management. 4th ed. Philadelphia: WB Saunders, 1999;367.

  4. Durlinger AL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Natchigal MW, et al. Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology 2002;143:1076-1084.

  5. Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, et al. Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod 2004;10:77-78.

  6. Baarends AR, Uilenbroek JT, Kramer P, Hoogerbrugge JW, vanLeeuwen EC, Themmen AP, et al. Anti-müllerian hormone and anti-müllerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle, and gonadotropin-induce follicle growth. Endocrinology 1995;136:4951-4962.

  7. Fanchin R, Schonauer LM, Righini C, Frydman N, Frydman R, Taieb J. Serum anti-Müllerian hormone dynamics during controlled ovarian hyperstimulation. Hum Reprod 2003;18:323-327.

  8. Fanchin R, Méndez Lozano DH, Louafi N, Achour- Frydman N, Frydman R, Taieb J. Dynamics of serum anti-Mullerian hormone levels during the luteal phase of controlled ovarian hyperstimulation. Hum Reprod 2005;20:747-751.

  9. Soto N, Iñiguez G, López P, Larenas G, Mujica V, Rey RA, et al. Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type I diabetes mellitus. Human Reprod 2009;24:2838-2844.

  10. Freeman EW, Gracia CR, Sammel MD, Lin H, Chong-Leon LL, Strauss JF III. Association of anti-müllerian hormone levels with obesity in late reproductive-age women. Fertil Steril 2007;87:101-106.

  11. Cramer SF, Patel A. The frequency of uterine leiomyomas. Am J Clin Pathol 1990;94:435-438.

  12. Mashal RD, Fejzo ML, Friedman AJ, Mitchner N, Nowak RA, Rein MS, et al. Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata. Genes Chromosomes Cancer 1994;11:1-6.

  13. Englund K, Blanck A, Gustavsson I, Lundkvist U, Sjoblom P, Norgren A, et al. Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment. J Clin Endocrinol Metab 1996;83:4092-4096.

  14. Otubu JA, Buttram VC, Besch NF, Besch PK. Unconjugated steroids in leiomyomas and tumor-bearing myometrium. Am J Obstet Gynecol 1982;143:130-133.

  15. Goldzieher JW, Maqueo M, Ricaud L, Aguilar JA, Canales E. Induction of degenerative changes in uterine myomas by high-dosage progestin therapy. Am J Obstet Gynecol 1966;96:1078-1087.

  16. Tiltman AJ. The effect of progestins on the mitotic activity of uterine fibromyomas. Int J Gynecol Pathol 1985;4:89-96.

  17. Carr BR, Marshburn PB, Weatherall PT, Bradshaw KD, Breslav NA, Byrd W, et al. An evaluation of the effect of gonadotropin-releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double blind, placebo-controlled, crossover trial. J Clin Endocrinol Metab 1993;76:1217-1223.

  18. Steinauer J, Pritts EA, Jackson R, Jacoby AF. Systematic review of mifepristone for the treatment of uterine leiomyomata. Obstet Gynecol 2004;103:1331-1336.

  19. Vigier B, Picard JY, Tran D, Legeai L, Josso N. Production of anti-müllerian hormone: another homology between Sertoli and granulose cells. Endocrinology 1984;114:1315-1320.

  20. Cohen-Haguenauer O, Picard JY, Mattei MG, Serero S, Nguyen VC, De Tand MF, et al. Mapping of the gene for antimüllerian hormone to the short arm of human chromosome 19. Cytogenet Cell Gener 1987;44:2-6.

  21. Jaffe RB. Disorders of sexual development. In: Yen SSC, Jaffe RB, Barbieri RL. Eds. Reproductive endocrinology. Physiology, pathophysiology and clinical management. 4th ed. Philadelphia: WB Saunders, 1999;367.

  22. Durlinger AL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Natchigal MW, et al. Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology 2002;143:1076-1084.

  23. Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, et al. Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod 2004;10:77-78.

  24. Baarends AR, Uilenbroek JT, Kramer P, Hoogerbrugge JW, vanLeeuwen EC, Themmen AP, et al. Anti-müllerian hormone and anti-müllerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle, and gonadotropin-induce follicle growth. Endocrinology 1995;136:4951-4962.

  25. Fanchin R, Schonauer LM, Righini C, Frydman N, Frydman R, Taieb J. Serum anti-Müllerian hormone dynamics during controlled ovarian hyperstimulation. Hum Reprod 2003;18:323-327.

  26. Fanchin R, Méndez Lozano DH, Louafi N, Achour- Frydman N, Frydman R, Taieb J. Dynamics of serum anti-Mullerian hormone levels during the luteal phase of controlled ovarian hyperstimulation. Hum Reprod 2005;20:747-751.

  27. Soto N, Iñiguez G, López P, Larenas G, Mujica V, Rey RA, et al. Anti-Müllerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type I diabetes mellitus. Human Reprod 2009;24:2838-2844.

  28. Freeman EW, Gracia CR, Sammel MD, Lin H, Chong-Leon LL, Strauss JF III. Association of anti-müllerian hormone levels with obesity in late reproductive-age women. Fertil Steril 2007;87:101-106.

  29. Cramer SF, Patel A. The frequency of uterine leiomyomas. Am J Clin Pathol 1990;94:435-438.

  30. Mashal RD, Fejzo ML, Friedman AJ, Mitchner N, Nowak RA, Rein MS, et al. Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata. Genes Chromosomes Cancer 1994;11:1-6.

  31. Englund K, Blanck A, Gustavsson I, Lundkvist U, Sjoblom P, Norgren A, et al. Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment. J Clin Endocrinol Metab 1996;83:4092-4096.

  32. Otubu JA, Buttram VC, Besch NF, Besch PK. Unconjugated steroids in leiomyomas and tumor-bearing myometrium. Am J Obstet Gynecol 1982;143:130-133.

  33. Goldzieher JW, Maqueo M, Ricaud L, Aguilar JA, Canales E. Induction of degenerative changes in uterine myomas by high-dosage progestin therapy. Am J Obstet Gynecol 1966;96:1078-1087.

  34. Tiltman AJ. The effect of progestins on the mitotic activity of uterine fibromyomas. Int J Gynecol Pathol 1985;4:89-96.

  35. Carr BR, Marshburn PB, Weatherall PT, Bradshaw KD, Breslav NA, Byrd W, et al. An evaluation of the effect of gonadotropin-releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double blind, placebo-controlled, crossover trial. J Clin Endocrinol Metab 1993;76:1217-1223.

  36. Steinauer J, Pritts EA, Jackson R, Jacoby AF. Systematic review of mifepristone for the treatment of uterine leiomyomata. Obstet Gynecol 2004;103:1331-1336.




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