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2013, Number 2

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Arch Inv Mat Inf 2013; 5 (2)

Manejo odontopediátrico de paciente con leucemia linfoblástica aguda

Santiago MC, Espinoza HSC

Language: Spanish
References: 21
Page: 74-79
PDF size: 411.16 Kb.


ABSTRACT

Acute leukemia is the most common type of cancer in children. Acute lymphoblastic leukemia accounts for 80% of the total number of cases of acute leukemia among children. The etiology of acute leukemia is unknown, but many predisposing genetic, environmental, and viral factors have been implicated. The clinical manifestations of leukemia are a direct result of the marrow invasion and resultant cytopenias (anemia, thrombocytopenia, and leukopenia). The diagnosis of acute leukemia requires the presence of 25% or more blasts in the bone marrow. Treatment lasts for a minimum of two years. The role of the dentist in the care of these special patients is vital importance in regard to the diagnosis, treatment and prevention of oral manifestations both early and late, to give the best possible handling odontopediatric to the patient with acute lymphoblastic leukemia and therefore a better quality of life. The diagnosis is made by the morphology analysis, molecular cytogenetic and bone marrow aspirate. The treatment lasts for approximately two years. The prognosis for children with acute lymphoblastic leukemia has improved dramatically in recent decades thanks to new drugs and in the last few years thanks to a risk-adapted treatment of patients.


REFERENCES

  1. Reiter A, Schrappe M, Ludwing WD, Hiddemann W, Sauter S, Henze G et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86, Blood, 1994; 84: 3122-3133.

  2. Dorantes-Acosta E, Zapata-Tarrés M, Miranda-Lora A, Medina-Sansón A, Reyes-López A, Peña del Casillo H et al. Comparación de las características clínicas al diagnóstico de niños con leucemia linfoblástica aguda afiliados al Seguro Popular, con respecto al desenlace, Bol Med Hosp Infant Mex, 2012; 69 (3): 190-196.

  3. Quintana J, Beresi V, del Pozo H et al. Leucemia linfoblástica aguda, Rev Chil Pediatr, 1987; 58: 219-224.

  4. Pui C-H, Evans WE. Acute lymphoblastic leukemia, New Engl J Med, 1998; 339: 605-615.

  5. Boj JR, Catalá M, García BC, Mendoza A. Odontopediatría, 1ª ed. Elsevier-Masson; Barcelona; 2004: pp. 349-352.

  6. Schorin MA, Blattner S, Gelber RD, Tarbell NJ, Donnelly M, Dalton V et al. Treatment of childhood acute lymphoblastic leukemia: results of Dana-Farber Cancer Institute/Children’s Hospital Acute Lymphoblastic Leukemia Consortium Protocol 85-01, J Clin Oncol, 1994; 12: 740-747.

  7. Vargas L. Avances en el tratamiento del cáncer infantil en Chile. Diez años del Programa Infantil Nacional de Drogas (PINDA), Rev Chil Pediatr, 1998; 69: 270-275.

  8. Benett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposals for the classification of the acute leukemias. French-American-British (FAB) cooperative group, Br J Haematol, 1976; 33: 451-458.

  9. Leucemia, segunda causa de muerte infantil. 04/02/2008. En: Periódico Digital.mx: http://periodicodigital.com.mx/notas/leucemia_segunda_causa_de_muerte_infantil1202104800#.UK4jRpjc5EQ

  10. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations, Br J Haematol, 1981; 47: 553-561.

  11. Shuster JJ, Wacker P, Pullen J, Humbert J, Land VJ, Mahoney Jr DR et al. Prognostic significance of sex in childhood B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group Study, J Clin Oncol, 1998; 16: 2854-2863.

  12. Piu CH, Frankel LS, Carrol AJ, Raimondi SC, Shuster JJ, Head DR et al. Clinical characteristics and treatment outcome of childhood acute lymphoblatic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases, Blood, 1991; 77: 440-447.

  13. Piu CH, Relling MV, Downing JR. Acute lymphoblastic leukemia, N Eng J Med, 2004; 350: 1535-1548.

  14. Piu CH, Sadlund JT, Pei D, Campana D, Rivera GK, Ribeiro RC et al. Improved outcome for children with acute lymphoblastic leukemia: results of total therapy study XIIIB at St. Jude Children’s Research Hospital, Blood, 2004; 104: 2690-2696.

  15. Piu CH, Carroll WL, Meshinchi S, Arceci RJ. Biology, risk stratification, and therapy of pediatric acute leukemias: an update, J Clin Oncol, 2011; 29: 551-565.

  16. Young YL Jr, Miller RW. Incidence of malignant tumours in U.S. children, J Pediatr, 1975; 86: 254-258.

  17. Vargas L, Pino S, Barría M et al. Aspectos clínicos y hematológicos iniciales de la leucemia en el niño, Rev Chil Pediatr, 1981; 55: 149-154.

  18. dos Santos OJ, Ventiades JA, Fontana LNN, Miranda FC. Conducta odontológica en pacientes pediátricos portadores de leucemia, Rev Cubana Estomatol, 2007; 44 (4): 1-9.

  19. Lopes NN, Petrilli AS, Caran EM, França CM, Chilvarque I, Lederman H. Dental abnormalities in children submitted to antineoplastic therapy, J Dental Child (Chic), 2006; 73: 140-145.

  20. Guggenheimer J. Oral manifestations of drug therapy, Dent Clin North Am, 2002; 46 (4): 857-868.

  21. Gomes MF, Kohlemann KR, Plens G, Silva MM, Pontes EM, da Rocha JC. Oral manifestations during chemotherapy for acute lymphoblastic leukemia: a case report, Quintessence Int, 2005; 36: 307-313.




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