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TIP Revista Especializada en Ciencias Químico-Biológicas

2013, Number 2

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TIP Rev Esp Cienc Quim Biol 2013; 16 (2)

Los factores de transcripción tipo Myb, una familia de reguladores de la diferenciación celular conservada en los organismos eucariontes

Arratia J, Aguirre J

Language: Spanish
References: 58
Page: 98-108
PDF size: 600.67 Kb.


ABSTRACT

Myb family proteins are ubiquitous in eukaryotes, and contain a characteristic DNA binding domain called Myb domain. The Myb domain consists in a conserved amino acid sequence (50-53 amino acids) that can be repeated from two (essential domain for DNA binding) to four times in the same protein. In plants, the Myb family is very numerous while in animals there are only three members; at least, one member of this family has been identified in other eukaryotes. Myb proteins participate as transcriptional activators or repressors in the regulation of fundamental cellular processes in metabolism or cell differentiation. Activity from Myb proteins is regulated through several post-translational modifications: redox state, phosphorylation and ubiquitylation stand out among them.


REFERENCES

  1. Klempnauer, K.H., Gonda, T.J. & Bishop, J.M. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell 31, 453-463, doi:0092-8674(82)90138-6 [pii] (1982).

  2. Du, H. et al. Biochemical and molecular characterization of plant MYB transcription factor family. Biochemistry (Mosc) 74, 1-11, doi:BCM74010005 [pii] (2009).

  3. Oh, I.H. & Reddy, E.P. The myb gene family in cell growth, differentiation and apoptosis. Oncogene 18, 3017-3033, doi:10.1038/sj.onc.1202839 (1999).

  4. Stober-Grasser, U. et al. The Myb DNA-binding domain is highly conserved in Dictyostelium discoideum. Oncogene7, 589-596 (1992).

  5. Rubio, V. et al. A conserved MYB transcription factor involved in phosphate starvation signaling both in vascular plants and in unicellular algae. Genes Dev. 15, 2122-2133, doi:10.1101/ gad.204401 (2001).

  6. Meneses, E. et al. The R2R3 Myb protein family in Entamoeba histolytica. Gene 455, 32-42, doi:S0378-1119(10)00062-4 [pii] 10.1016/j.gene.2010.02.004 (2010).

  7. Wieser, J. & Adams, T.H. flbD encodes a Myb-like DNA-binding protein that coordinates initiation of Aspergillus nidulans conidiophore development. Genes Dev. 9, 491-502 (1995).

  8. Sakura, H. et al. Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene. Proc. Natl. Acad. Sci. USA 86, 5758-5762 (1989).

  9. Dubos, C. et al. MYB transcription factors in Arabidopsis. Trends Plant Sci. 15, 573-581, doi:S1360-1385(10)00153-6 [pii] 10.1016/j.tplants.2010.06.005 (2010).

  10. Saikumar, P., Murali, R. & Reddy, E.P. Role of tryptophan repeats and flanking amino acids in Myb-DNA interactions. Proc. Natl. Acad. Sci. USA 87, 8452-8456 (1990).

  11. Ogata, K. et al. The cavity in the hydrophobic core of Myb DNAbinding domain is reserved for DNA recognition and transactivation. Nat. Struct. Biol. 3, 178-187 (1996).

  12. Ording, E., Kvavik, W., Bostad, A. & Gabrielsen, O.S. Two functionally distinct half sites in the DNA-recognition sequence of the Myb oncoprotein. Eur. J. Biochem. 222, 113-120 (1994).

  13. Ogata, K. et al. Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb. Nat. Struct. Biol. 2, 309-320 (1995).

  14. Biedenkapp, H., Borgmeyer, U., Sippel, A.E. & Klempnauer, K.H. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Nature 335, 835-837, doi:10.1038/335835a0 (1988).

  15. Weston, K. Extension of the DNA binding consensus of the chicken c-Myb and v-Myb proteins. Nucleic Acids Res. 20, 3043-3049 (1992).

  16. Ogata, K. et al. Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell 79, 639-648, doi:0092-8674(94)90549-5 [pii] (1994).

  17. Tahirov, T.H. et al. Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. Cell 108, 57-70, doi:S0092867401006365 [pii] (2002).

  18. Aasland, R., Stewart, A.F. & Gibson, T. The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB. Trends Biochem. Sci. 21, 87-88, doi:0968-0004(96)30009-1 [pii] (1996).

  19. Boyer, L.A. et al. Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes. Mol. Cell 10, 935-942, doi:S1097276502006342 [pii] (2002).

  20. Mo, X., Kowenz-Leutz, E., Laumonnier, Y., Xu, H. & Leutz, A. Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain. Genes Dev. 19, 2447-2457, doi:gad.355405 [pii] 10.1101/gad.355405 (2005).

  21. Lipsick, J.S. One billion years of Myb. Oncogene 13, 223-235 (1996).

  22. Rosinski, J.A. & Atchley, W.R. Molecular evolution of the Myb family of transcription factors: evidence for polyphyletic origin. J. Mol. Evol. 46, 74-83 (1998).

  23. Bergholtz, S. et al. The highly conserved DNA-binding domains of A-, B- and c-Myb differ with respect to DNA-binding, phosphorylation and redox properties. Nucleic Acids Res. 29, 3546-3556 (2001).

  24. Martin, C. & Paz-Ares, J. MYB transcription factors in plants. Trends Genet13, 67-73, doi:S0168952596100494 [pii] (1997).

  25. Jiang, C., Gu, J., Chopra, S., Gu, X. & Peterson, T. Ordered origin of the typical two- and three-repeat Myb genes. Gene 326, 13-22, doi:S0378111903009053 [pii] (2004).

  26. Kranz, H.D. et al. Towards functional characterisation of the members of the R2R3-MYB gene family from Arabidopsis thaliana. Plant J. 16, 263-276 (1998).

  27. Romero, I. et al. More than 80R2R3-MYB regulatory genes in the genome of Arabidopsis thaliana. Plant J. 14, 273-284 (1998).

  28. Rabinowicz, P.D., Braun, E.L., Wolfe, A.D., Bowen, B. & Grotewold, E. Maize R2R3 Myb genes: Sequence analysis reveals amplification in the higher plants. Genetics 153, 427- 444 (1999).

  29. Feller, A., Machemer, K., Braun, E.L. & Grotewold, E. Evolutionary and comparative analysis of MYB and bHLH plant transcription factors. Plant J. 66, 94-116, doi:10.1111/j.1365- 313X.2010.04459.x (2011).

  30. Zhang, Y., Cao, G., Qu, L.J. & Gu, H. Involvement of an R2R3- MYB transcription factor gene AtMYB118 in embryogenesis in Arabidopsis. Plant Cell Rep. 28, 337-346, doi:10.1007/ s00299-008-0644-4 (2009).

  31. Jin, H. & Martin, C. Multifunctionality and diversity within the plant MYB-gene family. Plant Mol. Biol. 41, 577-585 (1999).

  32. Lu, S.X., Knowles, S.M., Andronis, C., Ong, M.S. & Tobin, E.M. Circadian clock associated and late elongated hypocotyl function synergistically in the circadian clock of Arabidopsis. Plant Physiol. 150, 834-843, doi:pp.108.133272 [pii] 10.1104/ pp.108.133272 (2009).

  33. Wykoff, D.D., Grossman, A.R., Weeks, D.P., Usuda, H. & Shimogawara, K. Psr1, a nuclear localized protein that regulates phosphorus metabolism in Chlamydomonas. Proc. Natl. Acad. Sci. USA 96, 15336-15341 (1999).

  34. Yang, T., Perasso, R. & Baroin-Tourancheau, A. Myb genes in ciliates: a common origin with the myb protooncogene? Protist 154, 229-238 (2003).

  35. Myrset, A.H. et al. DNA and redox state induced conformational changes in the DNA-binding domain of the Myb oncoprotein. EMBO J. 12, 4625-4633 (1993).

  36. Guehmann, S., Vorbrueggen, G., Kalkbrenner, F. & Moelling, K. Reduction of a conserved Cys is essential for Myb DNAbinding. Nucleic Acids Res. 20, 2279-2286 (1992).

  37. Garzia, A., Etxebeste, O., Herrero-García, E., Ugalde, U. & Espeso, E.A. The concerted action of bZip and cMyb transcription factors FlbB and FlbD induces brlA expression and asexual development in Aspergillus nidulans. Mol. Microbiol.75, 1314- 1324, doi:MMI7063 [pii] 10.1111/j.1365-2958.2010.07063.x (2010).

  38. Arratia-Quijada, J., Sánchez, O., Scazzocchio, C. & Aguirre, J. FlbD, a Myb transcription factor of Aspergillus nidulans, is uniquely involved in both asexual and sexual differentiation. Eukaryot Cell 11, 1132-1142, doi:EC.00101-12 [pii] 10.1128/ EC.00101-12 (2012).

  39. Shen, W., Wieser, J., Adams, T.H. & Ebbole, D.J. The Neurospora rca-1 Gene Complements an Aspergillus flbD Sporulation mutant but Has No Identifiable Role in Neurospora Sporulation. Genetics 148, 1031-1041 (1998).

  40. Lin, Y. et al. A putative transcription factor MYT1 is required for female fertility in the ascomycete Gibberella zeae. PLoS One 6, e25586, doi:10.1371/journal.pone.0025586 PONE-D-11-13965 [pii] (2011).

  41. Lin, Y. et al. A putative transcription factor MYT2 regulates perithecium size in the ascomycete Gibberella zeae. PLoS One 7, e37859, doi:10.1371/journal.pone.0037859 PONE-D-12-07207 [pii] (2012).

  42. Pinson, B., Sagot, I., Borne, F., Gabrielsen, O.S. & Daignan- Fornier, B. Mutations in the yeast Myb-like protein Bas1p resulting in discrimination between promoters in vivo but notin vitro. Nucleic Acids Res. 26, 3977-3985, doi:gkb647 [pii] (1998).

  43. Pinson, B., Gabrielsen, O.S. & Daignan-Fornier, B. Redox regulation of AMP synthesis in yeast: a role of the Bas1p and Bas2p transcription factors. Mol. Microbiol. 36, 1460-1469, doi:mmi1966 [pii] (2000).

  44. Pinson, B., Brendeford, E.M., Gabrielsen, O.S. & Daignan-Fornier, B. Highly conserved features of DNA binding between two divergent members of the Myb family of transcription factors. Nucleic Acids Res. 29, 527-535 (2001).

  45. Pinson, B. et al. Signaling through regulated transcription factor interaction: mapping of a regulatory interaction domain in the Myb-related Bas1p. Nucleic Acids Res. 28, 4665-4673 (2000).

  46. Ramsay, R.G. & Gonda, T.J. MYB function in normal and cancer cells. Nat. Rev. Cancer 8, 523-534, doi:nrc2439 [pii] 10.1038/ nrc2439 (2008).

  47. Ness, S.A. Myb protein specificity: evidence of a context-specific transcription factor code. Blood Cells Mol. Dis. 31, 192-200, doi:S1079979603001517 [pii] (2003).

  48. Miglarese, M.R., Richardson, A.F., Aziz, N. & Bender, T.P. Differential regulation of c-Myb-induced transcription activation by a phosphorylation site in the negative regulatory domain. J. Biol. Chem. 271, 22697-22705 (1996).

  49. Morse, A.M., Whetten, R.W., Dubos, C. & Campbell, M.M. Posttranslational modification of an R2R3-MYB transcription factor by a MAP Kinase during xylem development. New Phytol. 183, 1001-1013, doi:NPH2900 [pii] 10.1111/j.1469- 8137.2009.02900.x (2009).

  50. Grasser, F.A., LaMontagne, K., Whittaker, L., Stohr, S. & Lipsick, J.S. A highly conserved cysteine in the v-Myb DNA-binding domain is essential for transformation and transcriptional trans-activation. Oncogene 7, 1005-1009 (1992).

  51. Brendeford, E.M., Myrset, A.H., Hegvold, A.B., Lundin, M. & Gabrielsen, O.S. Oncogenic point mutations induce altered conformation, redox sensitivity, and DNA binding in the minimal DNA binding domain of avian myeloblastosis virus v-Myb. J. Biol. Chem. 272, 4436-4443 (1997).

  52. Imamura, S. et al. R2R3-type MYB transcription factor, CmMYB1, is a central nitrogen assimilation regulator in Cyanidioschyzon merolae. Proc. Natl. Acad. Sci. USA 106, 12548-12553, doi:0902790106 [pii] 10.1073/pnas.0902790106 (2009).

  53. Lara-Ortiz, T., Riveros-Rosas, H. & Aguirre, J. Reactive oxygen species generated by microbial NADPH oxidase NoxA regulate sexual development in Aspergillus nidulans. Mol. Microbiol. 50, 1241-1255 (2003).

  54. Malagnac, F., Lalucque, H., Lepere, G. & Silar, P. Two NADPH oxidase isoforms are required for sexual reproduction and ascospore germination in the filamentous fungus Podospora anserina. Fungal Genet. Biol. 41, 982-997 (2004).

  55. Brendeford, E.M., Andersson, K.B. & Gabrielsen, O.S. Nitric oxide (NO) disrupts specific DNA binding of the transcription factor c-Myb in vitro. FEBS Lett. 425, 52-56, doi:S0014-5793(98)00196-3 [pii] (1998).

  56. Serpa, V. et al. Inhibition of AtMYB2 DNA-binding by nitric oxide involves cysteine S-nitrosylation. Biochem. Biophys. Res. Commun. 361, 1048-1053, doi:S0006-291X(07)01640-3 [pii] 10.1016/j.bbrc.2007.07.133 (2007).

  57. Heine, G.F., Hernández, J.M. & Grotewold, E. Two cysteines in plant R2R3 MYB domains participate in REDOX-dependent DNA binding. J. Biol. Chem. 279, 37878-37885, doi:10.1074/ jbc.M405166200 M405166200 [pii] (2004).

  58. Ganter, B., Chao, S.T. & Lipsick, J.S. Transcriptional activation by the myb proteins requires a specific local promoter structure. FEBS Lett. 460, 401-410, doi:S0014-5793(99)01373-3 [pii] (1999).




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