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TIP Revista Especializada en Ciencias Químico-Biológicas

2013, Número 2

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TIP Rev Esp Cienc Quim Biol 2013; 16 (2)


Los factores de transcripción tipo Myb, una familia de reguladores de la diferenciación celular conservada en los organismos eucariontes

Arratia J, Aguirre J

Idioma: Español
Referencias bibliográficas: 58
Paginas: 98-108
Archivo PDF: 600.67 Kb.


RESUMEN

La familia de proteínas Myb, ubicua en los eucariontes, se caracteriza por la presencia de un dominio de unión al ADN característico denominado dominio Myb. Éste consiste en una secuencia de aminoácidos conservados (50-53 aminoácidos) que puede estar repetida entre dos (dominio mínimo de unión al ADN) y hasta cuatro veces en la misma proteína. En las plantas, la familia Myb es muy numerosa, mientras que en los animales sólo se encuentran tres miembros, y en otros eucariontes se ha identificado al menos a un miembro de esta familia. Las proteínas Myb participan como activadores o represores transcripcionales en la regulación de procesos celulares fundamentales en el metabolismo o la diferenciación celular. La actividad de las proteínas Myb se regula a través de diversas modificaciones post-traduccionales dentro de las que destacan el estado redox, la fosforilación y la ubiquitinación.


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