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2013, Number 3

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Rev Hematol Mex 2013; 14 (3)

Testicular non-Hodgkin´s lymphoma in a child. Report of a case

López A, González-Llano Ó, Ramírez AC, Corolla M, Gómez-Almaguer D, Alvarado Y

Language: Spanish
References: 19
Page: 154-157
PDF size: 767.58 Kb.


ABSTRACT

Non-Hodgkin lymphoma (NHL) and Hodgkin disease are the third cause of cancer in childhood. The testis involvement as an initial manifestation is rare at this age, so it is not usually considered as a differential diagnosis in children with testicular tumor. We present a five years old child with increase in size in left testicle, with no other symptoms. Orchiectomy was performed. The pathology report was positive for B-cell lymphoblastic lymphoma with the following markers CD10, TdT, CD34, PAX5. In the extension studies, infiltration in central nervous system and bone marrow was negative. We classified the disease as stage II of the staging system of St. Jude’s Hospital. We started treatment with the COG 5971 protocol and obtained, until now, very good results. Good prognosis is related to a prompt diagnosis and therapeutic intervention.


REFERENCES

  1. Ries LA, Smith MA, Gurney JG. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. National Cancer Institute 1999;179.

  2. Li J, Trevor D, Thompson BS. Cancer incidence among children and adolescent in the Unites States 2001-2003. Pediatrics 2008;6:el470-el477.

  3. Ramirez A. Principales tipos de cáncer diagnosticados en la Unidades Médicas Acreditadas (UMA) de la Secretaría de Salud, para la atención de niños y adolescentes con cáncer en 2007 y 2008. Centro Nacional para la Salud de la Infancia y la Adolescencia.

  4. Termuhlen A, Gross T, Park J. Overview of pediatric non- Hodgkin lymphoma. FALTAN DATOS

  5. Garcia VA, Alobeid B, Traina MJ, et al. Isolated Primary Testicular B Lymphoblastic Lymphoma: An unusual presentation. J Pediatr Hematol Oncol 2013;35:e88-e90.

  6. Larrange JL, Ramaioli A, Theodore Ch. Non-Hodgkins lymphoma of the testis: A retrospective study of 84 patients treated in the French anticancer centres. Annals of Oncology 2001;12:1313-1319.

  7. Dalle JH, Mechinaud F, Michon J, et al. Testicular disease in childhood B-cell Non. Hodgkins lymphoma. The French Society of Pediatric Oncology experience. J Clin Oncol 2001;19:2397-2403.

  8. Kellie SJ, Pui CH, Murphy SB. Childhood Non-Hodgkins Lymphoma involving the testis: clinical features and treatment outcome. J Clin Oncol 1989;7:1066-1077.

  9. Cortelazzo S, Ponzoni M, Ferreri AJM. Lymphoblastic lymphoma. Critical Reviews in oncology/Hematology 2011;79:330-343.

  10. Rivera Luna R. Linfoma linfoblástico. Protocolos técnicos. Cáncer en niños. México: Editores Mexicanos, 2010;119- 127.

  11. Termuhlen A, Smith Lynett, Perkins S. Outcome of newly diagnosed children and adolescents with localized lymphoblastic lymphoma treated on children´s oncology group trial A5971: A report from Children´s oncology group. Pediatr Blood Cancer 2010;59:1229-1233.

  12. Haddy TB, Sandlund JT, Magrath IT. Testicular involvement in young patients with non-Hodgkins lymphoma. Am J Pediatr Hematolog Oncol 1988;10:224-229.

  13. Koukourakis G. Kouloulias V. Lymphoma of the testis as primary location: tumor review. Clin Trans Oncol 2010;5:321-325.

  14. Bujons A, Sfulcini C, Pascual M. Prepubertal testicular tumors and efficacy of testicular preserving surgery. BJU International 2010;107:1812-1815.

  15. Kumari M, Husain N, Babu S. Bilateral primary B-cell lymphoma of testis in a three years old male child. Indian Journal of Pathology and Microbiology 2010;53:181-182.

  16. Mousa A, Abbadi A, Hattab E. Primary testicular and paratesticular lymphoma. A restrospective clinicopathologic study of 34 cases with emphasis on differential diagnosis. Arch Pathol Lab Med 2007;131:1040-1046.

  17. Nogeira F, Petrilli S, Macedo D. Testicular tumors in children and adolescents. J Pediatr (Rio J) 2012;88:87-92.

  18. McDonald M, Reed A, Tran P. Testicular tumor ultrasound characteristics and association with histopathology. Urol Int 2012;89:196-202.

  19. Wang W, Gong ZH, Dai YT. Value of ultrasonography in the diagnosis and differential diagnosis of testicular tumor. National Journal of Andrology 2007;13:424-427.




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