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2013, Number 3

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VacciMonitor 2013; 22 (3)

Neuroimmunological response in dengue virus encephalitis

Padilla-Docal B, Wainshtok-Tomás D, Martínez-Larrarte JP, Rivero-Arias E, Herrera- Wainshtok A, Callol-Barroso J, Dorta-Contreras AJ

Language: Spanish
References: 20
Page: 9-13
PDF size: 95.58 Kb.


ABSTRACT

Dengue virus is a RNA virus of the Flaviviridae family including also West Nile virus, Japanese encephalitis virus and yellow fever virus. A retrospective study with three patients diagnosed with encephalitis associated with dengue virus was carried out. Using their sera and cerebrospinal fluid samples the levels of high class of immunoglobulins by radial immunodiffusion and mannan binding lectin were quantified by fluorometry three classes of immunoglobulins levels were quantified by using an immunodiffusion technique. Mannose-binding lectin was quantified by fluorometry. A retrospective study with three patients diagnosed with encephalitis. The Reibergram has shown three classes of immunoglobulins intrathecal synthesis and absence of mannan binding lectin synthesis. Differences in the immunoglobulin intrathecal synthesis percent were observed, which were related with the moment of virus infection and the onset of neurological manifestations compatible with encephalitis. This is the first report of neurological affectations in Cuban patients with dengue fever. The intrathecal immune response may be used for the best knowledge of the disease and for the contribution to the development of possible candidate vaccine.


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