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2013, Number 5

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Cir Cir 2013; 81 (5)

Caloric restriction: about its positive metabolic effects and cellular impact

Ortiz-Bautista RJ, Aguilar-Salinas CA, Monroy-Guzmán A

Language: Spanish
References: 43
Page: 459-464
PDF size: 357.92 Kb.


ABSTRACT

Caloric restriction, as a 30 to 60% decrease of ad libitum balanced caloric intake, without malnutririon, is the non-genetic strategy that has consistently extended the average and maximum lifespan of most living beings, and it has been tested from unicellular organisms like yeast Saccharomyces cerevisiae to Rhesus primates. In addition, various genetic and pharmacological caloric restriction models have shown to protect against cancer, cardiovascular and neurodegenerative diseases. Primate studies suggest that this intervention delays the onset of age-related diseases; in humans, it has physiological, biochemical and metabolic effects decreasing diabetes and cardiovascular disease risk factor. Although currently the mechanism by which caloric restriction has its positive effects at the cellular level is unknown, it has been reported to decrease oxidative stress and increase in mitochondrial biogenesis.


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