2013, Number 4
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Rev Mex Patol Clin Med Lab 2013; 60 (4)
Prevalence of platelet donors with high titers of anti-a and anti-b
Medécigo LAL, Cázares TR, Pérez CF, Díaz OC
Language: Spanish
References: 18
Page: 230-234
PDF size: 126.64 Kb.
ABSTRACT
Background: Hemolytic transfusion reactions can occur from ABO-incompatible platelet transfusions so reducing this risk has been an area of increasing interest in recent years.
Methods: We conducted a prospective study to determine the prevalence of donors with high titles of ABO antibodies in the Blood Bank of the University Hospital «Dr. José Eleuterio González» in Monterrey, Nuevo León. In which, 313 donors were included,
Results: 128 (40%) were labeled as high titles of ABO antibodies. 86 (48%) of group O were labeled high titles, whose specificity in 23 (27%) was anti-a, 34 (39%) anti-b and 29 (34%) anti-A and anti-b. 33 (33%) of group A donors are labeled as high titles of anti-b and 9 (26%) of group B are labeled as high titles of anti-a.
Conclusion: We found a high prevalence of donors with high titles of ABO antibodies, so we need to screening donors for high title ABO antibodies. It is recommended to study in other areas of the country.
REFERENCES
Radillo GA. Medicina Transfusional. México: Editorial Prado; 2006.
Fung MK, Downes KA, Shulman IA. Transfusion of platelets containing ABO-incompatible plasma. Arch Pathol Lab Med. 2007; 131: 909-916.
Kelton JG, Hamid C, Aker S, Blajchman MA. The amount of blood group A substance on platelets is proportional to the amount in the plasma. Blood. 1982; 59: 980-985.
Dunstan RA, Simpson MB, Knoweles RW, Rosse WF. The origin of ABH antigens on human platelets. Blood. 1985; 65: 615-619.
Blood transfusion practice. In: Brecher ME (ed). Technical Manual. 15th ed. Bethesda, Md: AABB; 2005. p. 490-491.
Cooling LL, Kelly K, Barton J, Hwang D, Koerner TA, Olsonn JD. Determinants of ABH expression on human blood platelets. Blood. 2005; 105: 3356-3364.
Cooling L. ABO and platelet transfusion therapy. Immunohematology. 2007; 23: 20-33.
Standards for Blood Banks and Transfusion Services, Standard 5.14.4.23rd. ed. Bethesda, Md: AABB; 2004.
Josephson CD, Mullis NC, Van Demark C, Hillyer CD. Significant numbers of apheresis-derived group O platelet units have “high-titer” anti-A/A,B: implications for transfusion policy. Transfusion. 2004; 44: 805-808.
Larsson LG, Welsh VJ, Ladd DJ. Acute intravascular hemolysis secondary to out-of-group platelet transfusion. Transfusion. 2000; 40: 902-906.
Lozano M, Cid J. The clinical implications of platelet transfusions associated with ABO and Rh (D) incompatibility. Transfus Med Rev. 2003; 17: 57-68.
Valbonesi M, Deluigi MC, Lercari G et al. Acute intravascular hemolysis in two patients transfused with dry-platelets units obtained from the same ABO incompatible donor. Int J Artif Organs. 2000; 23: 642-646.
Pietersz RNI, Engelfriet CP, Reesink HW. International Forum: Transfusion of apheresis platelets and ABO groups. Vox Sang. 2005; 88: 207-221.
Consensus conference. Platelet transfusion therapy. JAMA. 1987; 257: 1777-1780.
The Serious Hazards of Transfusion Steering Group. Serious hazards of transfusion (SHOT) 2003 annual report (UK). Manchester, United Kingdom.
Mazda T, Yabe R, NaThalang O, Thammavong T, Tadokoro K. Differences in ABO antibody among blood donors: a comparision between past and present Japanese, Laotian and Thai populations. Immunohematology. 2007; 23 (1): 38-41. Erratum in: Immunohematology. 2008; 24 (1): 28.
Doron S, Gorbach SL. Probiotics: their role in the treatment and prevention of disease. Expert Rev Anti Infect Ther. 2006; 4: 261-275.
Karafin M, Blagg L, Tobian A et al: ABO titles are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions. Transfusion. 2012.
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