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2013, Number 4

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Rev Mex Patol Clin Med Lab 2013; 60 (4)

New observations on the polar spectrum of human leprosy 1. Clinical types, histopathology, immunology

Carrada BT

Language: English
References: 127
Page: 205-223
PDF size: 1252.17 Kb.


ABSTRACT

Leprosy is a chronic granulomatous infection of the skin and peripherial nerves, caused by Mycobacterium leprae. Leprosy clinical diagnosis should be considered whenever skin lesions and sensory loss occur. Recent immunologic research, classic bacteriological methods and histopathology, molecular bacteriology and the Ridley-Jopling (RJ) classification which recognized clinical-types not as separate entities, but merely segments of a wide spectrum ranging from purely localized, hyperergic, tuberculoid (TT) pole, trough the borderline (B) types, to the generalized, anergic lepromatous (LL) pole. Reactive episodes continue to be a serious complication, but the availability of thalidomide and clofazimine to control erythema nodosum leprosum, has much improved the prognosis. This review summarises recent advances in understanding the clinical features and pathogenesis of the disease.


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