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Academia Mexicana de Neurología, A.C.

2013, Number 3

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Rev Mex Neuroci 2013; 14 (3)

Saccadic eye movements abnormalities in polyglutamine diseases

Rodríguez-Labrada R, Velázquez-Pérez L

Language: Spanish
References: 65
Page: 150-158
PDF size: 250.01 Kb.


ABSTRACT

Polyglutamine diseases comprise a group of neurodegenerative diseases caused by expansion of citosine-adenine-guanine (CAG) repeats in coding regions of specific genes. Among its phenotypical features, the saccadic abnormalities are very common. Saccades allow us to shift, rapidly and accurately, the attention from a target to other in the visual scene. Saccadic eye movements are generated by an extensive cortical-subcortical circuitry and they are usually used as important tools in basic and clinical researches of nervous central system. This paper presents an updated review of saccadic abnormalities in polyglutamine diseases, emphasizing in the usefulness of these features for diagnosis and disease biomarkers identifications. Saccadic abnormalities in polyglutamine diseases point out the marked vulnerability of saccadic system to CAG expansions. Its study allows us to identify useful parameters for early diagnosis and disease biomarkers for therapies evaluation. Nevertheless, other studies are mandatory to get deep into the pathophysiology of these oculomotor abnormalities.


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