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Academia Mexicana de Neurología, A.C.

2013, Number 3

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Rev Mex Neuroci 2013; 14 (3)

Working memory in women with multiple sclerosis during the menstrual cycle

Silva-Vera M, Solís-Ortiz S, Pérez-Luque E

Language: Spanish
References: 23
Page: 127-132
PDF size: 136.53 Kb.


ABSTRACT

Introduction: Multiple sclerosis (MS) occurs more often in women, suggesting that sex hormones appear to modulate the expression of symptoms. There has been an increase in symptoms before menstruation, and the number of injuries associated with the proportion of progesterona/17-beta estradiol during the luteal phase.
Objective: To assess the working memory (WM) function in follicular and luteal phases of the menstrual cycle in women with MS.
Methods: We evaluated women with MS aged 20-40 years, regular menstrual cycles, and disease duration of 5-10 years. They were compared with a group of healthy women. The recordings were made in the follicular and luteal phases of the menstrual cycle and correlated with hormone levels.
Results: The task of WM in women with MS showed a significantly poor performance compared to the performance of the control group. When comparing the performance of the task among themselves, women with MS in the luteal phase showed a significantly better performance with a larger number of categories achieved (p ‹ 0.004), fewer perseverative errors (p ‹ 0.003) and a greater number of tests to achieve a category (p ‹ 0.011). This performance was positively correlated with progesterone and LH.
Conclusions: The results indicate that WM improves in the luteal phase of the menstrual cycle, suggesting that progesterone seems to facilitate this cognitive domain.


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