López NJA, Chávez OA, Ríos MS, Ramos SP, Cubillo J

Language: Spanish
References: 37
Page: 3-8
PDF size: 198.97 Kb.

ABSTRACT

Objective: To determine concentrations of natural killer (NK) cells CD56+CD16+ by monoclonal antibodies in the endometrium of patients with unexplained recurrent abortion.
Patients and method: A prospective, longitudinal and descriptive study was done in which 20 patients with recurrent pregnancy loss of unknown origin were included. Endometrial biopsy was performed on day 21 to 26 of the menstrual cycle to assess the concentration of NK cells CD56+CD16+ by monoclonal antibodies. The results were compared with normal standards biopsies reported in fertile women. Statistical analysis included measures of central tendency, mean and proportions.
Results: Of 20 patients studied, 8 (40%) had elevated NK cells. In 3 (15%) levels were highly positive. In 12 (60%) levels were normal.
Conclusions: This study provides essential information about the importance and frequency of NK cells CD56+16+ in patients with recurrent pregnancy loss of unknown origin, and that in light of current knowledge are known to play a key role in the process of abortion. In this study we found that 40% of women with recurrent pregnancy loss had, in greater or lesser degree, these endometrial cells level.

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