López NJA, Chávez OA, Ríos MS, Ramos SP, Cubillo J

Idioma: Español
Referencias bibliográficas: 37
Paginas: 3-8
Archivo PDF: 198.97 Kb.

RESUMEN

Objetivo: determinar la concentración de células natural killer (NK) CD56+CD16+ por medio de anticuerpos monoclonales en el endometrio de pacientes con aborto recurrente de origen desconocido.
Pacientes y método: estudio prospectivo, longitudinal y descriptivo que incluyó 20 pacientes con pérdida gestacional recurrente de origen desconocido, a quienes se realizó biopsia endometrial los días 21 a 26 del ciclo menstrual para evaluar la concentración de células NK CD56+CD16+ por medio de anticuerpos monoclonales. Los resultados se compararon con estándares normales reportados en biopsias de mujeres fértiles. El análisis estadístico incluyó medidas de tendencia central, media y proporciones.
Resultados: de 20 pacientes estudiadas, en ocho (40%) se encontró elevación de células NK; en tres (15%) las concentraciones eran altamente positivas y en 12 (60%) eran normales.
Conclusiones: este estudio proporciona información esencial de la importancia y frecuencia de las células NK CD56+CD16+ en pacientes con pérdida recurrente de la gestación de origen desconocido, ya que a la luz de los conocimientos actuales se sabe que juegan un papel clave en el proceso del aborto. En este trabajo, se encontró que 40% de las mujeres con pérdida recurrente de la gestación tenían, en mayor o menor grado, estas células en el endometrio.

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