2013, Number 5
<< Back Next >>
Med Int Mex 2013; 29 (5)
New Markers of Acute Kidney Injury in Critically Ill Patients
Espinosa-Sevilla A, Amezcua-Macías AI, Ruiz-Palacios PC, Rodríguez-Weber F, Díaz-Greene E
Language: Spanish
References: 20
Page: 513-517
PDF size: 201.91 Kb.
ABSTRACT
The acute kidney injury (AKI) is a frequent complication in
critically ill patients as well as a major risk factor for the development
of renal complications, independently contributes to
patient mortality, therefore, their prophylaxis, so timely determination
as early intervention positively impact their evolution.
There are promising new biomarkers to achieve early
detection of AKI: Cystatin C, interleukin-18 (IL-18), injury
molecule-1 in renal (KIM-1), N-acetyl-bD-glucosaminidase
(NAG) sodium-hydrogen exchanger isoform-3 (NHE-3),
neutrophil gelatinase associated lipocalin (NGAL).
REFERENCES
Xue JL, Daniels F, Star RA, Kimmel PL, Eggers PW, Molitoris BA, et al. Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol 2006;17:1135-42.
Ravindra, L Metha, Kellum JA, Sudhir VS, et al. Acute Kidney Injury Network report of an initiative to improve outcomes in acute kidney injury. Critical Care 2007;11:1-8.
Adiyanti SS, Loho T. Acute Kidney Injury (AKI) Biomarker. The Indonesian Journal of Internal Medicine 2012;44:246-255.
Singbartl K, Kellum JA. AKI in the ICU: definition, epidemiology, risk, stratification and outcomes. Kidney International 2011; 81:818-825.
Belcher JM, Edelstein ChL, Parikh ChR. Clinical Applications of biomarkers for Acute Kidney Injury. American Journey Kidney Disease 2011;57:930-940.
Castaño Bilbao I, Slon Roblero MF, García Fernández N. Estudios de la función renal: función glomerular y tubular. Análisis de orina. NefroPlus 2009;2:17-30.
Tenorio MT, Galeno C, Rodríguez N, Liaño F. Diagnóstico diferencial de la insuficiencia renal aguda. NefroPlus 2010;3:16-32.
Liaño F, Pascual J. Epidemiology of acute renal failure: a prospective, multi-center, community- based study. Madrid Acute Renal Failure Study Group. Kidney Int 1996;50:811-8.
Gracie JA. Interleukin-18 as a potential target in inflammatory arthritis. Clin Exp Immunol 2004;136:402-404.
Li P, Allen H, Banerjee S, et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 1995;80:401-11.
Elevated Urinary IL-18 Levels at the Time of ICU Admission Predict Adverse Clinical Outcomes.
Parikh CR, Abraham E, Ancukiewicz M, Edelstein CL. Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol 2005;16:3046-52.
Parikh CR, Abraham E, Ancukiewicz M, et al., Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit, J Am Soc Nephrol, 2005;16:3046-52.
Vaidya VS, Ford GM, Waikar SS, et al. A rapid urine test for early detection of kidney injury. Kidney Int 2009;76:108-114.
Hilde RH, de Geus, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. Clean kidney J 2012;5:102-108.
Price RG. The role of NAG (N-acetyl-β-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity. Clin Nephrol 1992; 38 [Suppl]:14.
Rustom R, Castigan M, Shenkin A, et al. Proteinuria and renal tubular damage: urinary N-acetyl-β-Dglucosaminidase and isoenzymes in dissimilar renal disease. Am J Nephrol 1998; 18:179.
Mori K, Lee HT, Rapoport D, et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest. 2005;115:610-621.
Castaño Bilbao I, Slon Roblero MF, García Fernandez N. Estudios de la función renal: función glomerular y tubular. Análisis de orina. NefroPlus 2009;2:17-30.
Shemin D, Dworkin LD. Neutrophil gelatinase-associated lipocalin (NGAL) as a Biomarker for Early Acute Kidney Injury. Crit Care Clin 2011;27:379-389.