2013, Number 4
<< Back Next >>
Gac Med Mex 2013; 149 (4)
Corneal transplant in a second level hospital. A survival analysis
Hernández MSE, Paniagua JM, Gómez RG, Páez MRM
Language: Spanish
References: 18
Page: 425-430
PDF size: 82.97 Kb.
ABSTRACT
Objective: To determine the long-term corneal graft survival in patients of General Hospital Dr. Miguel Silva.
Materials
and methods: This was a retrospective cohort study. Records from patients who underwent corneal transplant surgery
at General Hospital Dr. Miguel Silva were analyzed. The percentages of graft failure were obtained. Kaplan-Meier
survival analysis was performed to evaluate the long-term cumulative probability of graft non-rejection in all patients
according to diagnosis.
Results: Overall, 71.9% (CI 95%: 64.8-78.9) of the patients did not have any graft rejections,
and 12.5% (CI 95%: 7-18) required a regraft and were considered graft failures. Patients with posttraumatic leucoma
had a cumulative probability of non-rejection of 100%. Subjects with keratoconus had a 65% likelihood of non-rejection
after 40 months of follow-up. The likelihood of non-rejection was greater than 80% at 100 months of follow-up in
pseudophakic bullous keratopathy patients and 60% at 20 months of follow-up in inactive herpetic leucoma patients.
Conclusions: Posttraumatic leucoma patients had the greatest cumulative survival probability compared with postherpetic
leucoma patients and other patient groups.
REFERENCES
McNeill JI. Indications and outcomes. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Krachmer’s cornea. 2.a ed. Philadelphia, PA: Elsevier- Mosby; 2005. p. 1413-22.
Dolorico AM, Tayyani R, Ong HV, Gaster RN. Shortterm and longterm visual and astigmatic results of an opposing 10-0 nylon double running suture technique for penetrating keratoplasty. J Am Coll Surg. 2003;197:991-9.
Smith VA, Johnson T. Evaluation of Megacell MEM as a storage medium for corneas destined for transplantation. Ophthalmic Res. 2010;43:18-25.
Küchle M, Cursiefen C, Nguyen NX, et al. Risk factors for corneal allograft rejection: intermediate results of a prospective normal-risk keratoplasty study. Graefes Arch Clin Exp Ophthalmol. 2002;240:580-4.
Niziol LM, Musch DC, Gillespie BW, Marcotte LM, Sugar A. Long-term outcomes in patients who received a corneal graft for keratoconus between 1980 and 1986. Am J Ophthalmol. 2013;155:213-9.
Foulks GN. Diagnosis and management of corneal allograft rejection. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Krachmer’s cornea. 3.a ed. Philadelphia, PA: Elsevier-Mosby; 2012. p. 1312-26.
Montiel HH. Trasplante de córnea. Criterio clínico-quirúrgico. Revista de Investigación Clínica. 2005;57:358-67.
Nijm LM, Mannis MJ, Holland EJ. The evolution of contemporary keratoplasty. In: Krachmer JH, Mannis MJ, Holland EJ, eds. 3.a ed. Krachmer’s cornea. Philadelphia, PA: Elsevier-Mosby; 2012. p. 1335-48.
Inoue K, Amano S, Oshika T, Tsuru T. Risk factors for corneal graft failure and rejection in penetrating keratoplasty. Acta Ophthalmol Scand. 2001;79:251-5.
Al-Mezaine H. Repeat penetrating keratoplasty: indications, graft survival, and visual outcome. Br J Ophthalmol. 2006;90:324-7.
Basu S, Reddy JC, Vaddavalli PK, Vemuganti GK, Sangwan VS. Longterm outcomes of penetrating keratoplasty for keratoconus with resolved corneal hydrops. Cornea. 2012;31:615-20.
Joshi SA, Jagdale SS, More PD, Deshpande M. Outcome of optical penetrating keratoplasties at a tertiary care eye institute in Western India. Indian J Ophthalmol. 2012;60:15-21.
Pan Q, Li X, Gu Y. Indications and outcomes of penetrating keratoplasty in a tertiary hospital in the developing world. Clin Experiment Ophthalmol. 2012;40:232-8.
Claesson M, Armitage WJ. Ten-year follow-up of graft survival and visual outcome after penetrating keratoplasty in Sweden. Cornea. 2009;28:1124-9.
Patel SV. Graft survival after penetrating keratoplasty. Am J Ophthalmol. 2011;151:397-8.
Halberstadt M, Machens M, Gahlenbek KA, Böhnke M, Garweg JG. The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin. Br J Ophthalmol. 2002;86:646-52.
Patel HY, Ormonde S, Brookes NH, et al. The New Zealand National Eye Bank: survival and visual outcome 1 year after penetrating keratoplasty. Cornea. 2011;30:760-4.
Jhanji V, Moorthy S, Constantinou M, Beltz J, Vajpayee RB. Penetrating keratoplasty for unilateral corneal disease: outcomes from a tertiary care hospital in Australia. Eye Contact Lens. 2010;36:6-9.