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Academia Mexicana de Neurología, A.C.

2013, Number 1

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Rev Mex Neuroci 2013; 14 (1)

Trends in clinical applications of melatonin in sleep disorders

Jiménez-Genchi A, Guarneros-Roniger DD, Barrera-Medina A, Laurel-Gardeazábal IE

Language: Spanish
References: 38
Page: 39-43
PDF size: 197.67 Kb.


ABSTRACT

Melatonin is an indolamine hormone produced by the pineal gland and its secretion follows a circadian rhythm determined by the absence of light. Chronobiotic and sleep promotion effects of melatonin are exerted through its binding to MT1 and MT2 receptors in the suprachiasmatic nucleus. These properties underlie its clinical applications in the treatment of insomnia, delayed sleep phase syndrome, jet lag, and maybe shift work disorder. Likewise, melatonin has been used for the management of REM sleep behavior disorder. There are several agonist drugs of melatonin receptors such as ramelteon, agomelatine and tasimelteon which have shown to produce similar effects to those found with melatonin.


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