2013, Number 1
Modifications of somatometric indicators associated with antioxidant defense in renourished rats after moderate undernourishment
Language: Spanish
References: 11
Page:
PDF size: 94.36 Kb.
ABSTRACT
Introduction: protein-energy malnutrition is the result of the imbalance between the needs of the organism and nutrient intake. It causes metabolic changes that increase morbi-mortality.Objective: to check the recovery of somatometric indicators and their correspondence with the variables of antioxidant defense during the renourishment of moderately undernourished rats.
Methods: An experimental prospective study was performed with a sample of 64 male Wistar albino rats at weaning (32 control and the rest of the experimental one) through a complete renourishment model for three weeks, after quantitative restrictions on 75 % of the daily requirement for their age during 28 days. Somatometric variables were determined and antioxidant defense indicators and their association, by Pearson's correlation coefficient. It was estimated the mean, the standard deviation and the t-Student test.
Results: during renourishment it was observed recovery of body weight of the experimental group (256.11 g) without reaching the normality of the control (270.98 g), size was increased (18,43 cm) and the length of the tail (14, 01 cm) of the experimental one without reaching the control (20.07 cm) and (15.05 cm) respectively. The weight of the organs was increased, standing out the liver (10.71 g) and the small intestine (4.41 g) of the experimental one without reaching control values (11.77 g) and (4.75 g) respectively.
Conclusions: alterations of somatometric indicators occurred in undernourishment are reversed during renourishment which is associated with the progressive increase in antioxidant defenses.
REFERENCES
León Rodríguez R, Santana Porbén S, Collazo Herrera M, Barreto Penié J. Costoefectividad de intervenciones alimentario-nutrimentales vs. hospitalización en pacientes colorrectales. Rev Cubana Farm [Internet]. 2003 [citado 10 Ene 2012];37(1). Disponible en: http://www.bvs.sld.cu/revistas/far/vol37_1_03/far02103.htm
Tannuri U, Carrazza FR, Iriya K. The effects of glutamine supplemented diet on the intestinal mucosa of the malnourish rats. Rev Hosp Clin Fac Med Sao Paulo [Internet]. 2000 May-Jun [cited 2012 Feb 10];55(3). Available from:http://www.scielo.br/scielo.php?pid=S0041- 87812000000300004&script=sci_arttext
Fernández Hernández J, Heuze de Icaza YM. El programa interno para el cuidado y uso de los animales de laboratorio en las instituciones biomédicas docentes, de investigación científica e industria farmacéutica. Acta Bioeth [Internet]. 2007 Jun [citado 25 Mar 2012];13(1). Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S1726- 569X2007000100003&lng=es.
Ciliberto H, Ciliberto M, Briend A, Ashorn P, Bier D, Manary M. Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomized, double blind, placebo controlled trial. BMJ [Internet]. 2005 May [cited 2012 Feb 10];330(7500). Available from: http://www.ncbi.nlm.nih.gov/pubmed/15851401