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2013, Number 4

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Cir Cir 2013; 81 (4)

Malignant mesothelioma risk factors, experience in the General Hospital of Mexico

Hernández-Solís A, Garcia-Hernández C, Reding-Bernal A, Cruz-Ortiz H, Cicero-Sabido R

Language: Spanish
References: 25
Page: 312-316
PDF size: 376.73 Kb.


ABSTRACT

Background: Malignant mesothelioma is a neoplasm of bad prognosis, it is linked with asbestos contact, but there are cases without this antecedent.
Objective: To investigate the relationship of asbestos exposition and other factors with malignant mesothelioma.
Methods: Retrospective analysis of histologic confirmed cases of malignant mesothelioma, neoplasic familiar history, tobacco smoking, exposition to wood smoke and to asbestos, were annotated in a paired case/control study 1: 1-3 with logistic regression model to identify risk factors for OR.
Results: 61 cases of malignant mesothelioma were confirmed by histopathologic study, 41 male and 20 female. Mean age was 56 years ± 13 years; 56 cases (91.8%) correspond to epithelial malignant mesothelioma, three sarcomatous (4.9%) one desmoplastic and one biphasic. One in eight (13.1%) had exposure to asbestos. Model of logistic regression with four variables: history of familiar cancer, tobacco smoking, wood smoke and asbesto exposition, the last one with an OR= 3.083 and p› 0.05. No other variables found to be a risk factor for malignant mesothelioma.
Conclusions: Exposure to asbestos is a risk factor for malignant mesothelioma, which is confirmed in this study, however it is important to extend the investigation of other possible causal factors of this disease.


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