2012, Number 3
<< Back Next >>
Rev Mex Neuroci 2012; 13 (3)
The virus HHV-6 and its effects on neurodevelopment: a case study
Dzib-Goodin A
Language: Spanish
References: 35
Page: 150-153
PDF size: 113.62 Kb.
ABSTRACT
At least since 1993 different papers around the world
have been published highlighting the viral infections
associated with neurodevelopmental disorders, including
febrile seizures, the medial temporal lobe epilepsy,
encephalitis, meningitis, and meningoencephalitis. All of
them produce neurocognitive sequels, which are
repeatedly confused with any of the autism spectrum
disorders. Around the world have been documented
cases where initial diagnosis has concealed the
presence of the virus. This article presents a case study of
a Mexican girl who was diagnosed and treated as
pervasive developmental disorder, until a different
protocol was carried out to analyze the differential diagnosis
and it was found she had the virus HHV-6, which
caused her chronic irritability in the frontal lobe and led
to a setback in development. Medical treatment
included support on diet and neuromodulation based
on brain plasticity, showing slow but sustainable changes.
REFERENCES
Donati D, Akhyani N, Fogdell-Hahn A, Cermelli C, Cassiani-Ingoni R, Vortmeyes A, Heiss JD, et al. Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections. Neurology 2003; 61: 1405-11.
Theodore WH, Epsetin L, Gallard WD, Shinnar S, Wainwright MS, Jacoboson S. Human Herpes virus 6B: A possible role in epilepsy? Epilepsia 2008; 49: 1828-37.
Jacobson S. The emerging role of HHV-6 in neurologic disease: lesson from multiple sclerosis and epilepsy. Retrovirology 2006; 3: S64.
Vinters HV, Wang R, Willey CA. Herpesviruses in chronic encephalitis associated with intractable childhood epilepsy. Hum Pathol 1993; 24: 871-9.
Libbey JE, Sweeten TL, McMahon WM, Fujiami RS. Autistic disorder and viral infections. J Neurovirol 2005; 11: 1-10.
Fotheringham J, Donati D, Akhyani N, Fogdell-Hahn A, Vortmeyer A, Heiss JD, et al. Association of Human Herpesvirus-6B with mesial temporal lobe epilepsy. Plos Medicine 2007. Available at: http://www.plosmedicine.org/ article/info%3Adoi%2F10.1371%2Fjournal.pmed.0040180
Nicolson GL, Gan R, Nicolson NL, Haier J. Evidence for Mycoplasma ssp., Chlamydia pneumonia, and human herpes virus-6 coinfections in blood patients with autistic spectrum disorders. J Neurosci Res 2007; 85: 1143-8.
Singh VK. Neuro-inmunopathogenesis in autism. NeuroInmune Biology 2007; 1: 447-58.
Shukla G, Prasad AN. Natural history of temporal lobe epilepsy: Antecedents and progression. Epilepsy Research and Treatment. 2012; Available at: http://www.hindawi.com/journals/ert/2012/195073/abs/
Osaghae DO, Mukwuzi-Odum NL, Sule G. Clinical presentation of febrile convulsions in Benin City. Nigerian Hospital Practice 2011; 17: 82-8.
Granata T, Cross H, Theodore W, Avanzin G. Inmune-mediated epilepsies. Immunity and inflammation in epilepsy. 2011; 52: 5-11.
Osaghae DO, Mukwuzi-Odum NL, Sule G. Clinical presentation of febrile convulsions in Benin City. Nigerian Hospital Practice 2011; 17: 82-8.
Matsumoto H, Hatanaka D, Ohura Y, Chida A, Nakamura Y, Nonoyama S. Severe human herpesvirus 6- associated encephalopathy in three children: Analysis of cytokine profiles and the carnitine palmitoyltransferasa 2 gene. Pediatr Infec Dis J 2011; 30: 999-1001.
Okuma A, Suzuki M, Kidoro Komatsu M, Shono T, Hayakawa F, Shimizu T. The spectrum of acute encephalopathy with reduced diffusion in the unilateral hemisphere. Eu J Pediatr Neurol 2009; 13: 154-9.
Nicholson GL, Gan R, Nicholson NL, Haier J. Evidence for Mycoplasma ssp., Chlamydia pneunomiae, and human herpes virus-6 coinfections in blood patients with autistic spectrum disorders. J Neuroscien Res 2007; 85: 1143-8.
Lanari M, Papa I, Venturi V, Lazzarotto T, Faldella G, Gabrielli L, Guerra B, et al. Congenital infection with human herpesvirus 6 variante B associated with neonatal seizures and for neurological outcome. J Med Virol 2003; 70: 628-32.
Prittchet JC, Nanau RM, Neuman MG. The link between hypersensivity syndrome reaction development and Human Herpes Virus- 6 reactivation. Internat J Hepathol 2012; Available at: http://www.hindawi.com/ journals/ijhep/2012/723062/abs/
Haberland E, Bast T, Ebner A, Holthausen H, Kluger G, Kravljanac R, et al. Limbic encephalistis in children and adolescents. Arch Dis Child 2011; 96: 186-91.
Revest M, Minjolle S, Veyer D, Lagathu G, Michelet C, Collimon R. Detection of HHV-6 in over a thousand samples: New types of infection revealed by an analysis of positive results. J Clin Virol 2011; 51: 20-4.
Gygax MJ, Deonna T, Maeder P, Mayor Dubois C, Roulet-Perez E. Acute infantile encephalopathy predomantly affecting the frontal lobe (AIEF): A European case 2011; 15: 158-62.
Hedlund GL. Comments on hippocampal scleroris in children younger than 2 years. Pediatric Radiol 2011; 41: 1229-31.
Goldberg M, Goldberg E, Mena I (eds.). The myth of autism: how a misunderstood epidemic is destroying our children. United States of America. Skyhorse Publishing. 2011.
Sanon NT, Desfent S, Carmant L. Atypical febrile seizure mesial temporal lobe epilepsy, and dual pathology. Epilepsy Research and Treatment. 2012; Available at: http://www.hindawi.com/journals/ert/2012/342928/
Chung B, Wong V. Relationship between five common viruses and febrile seizure in children. Arch Dis Child 2007; 92: 589-93.
Dzib A. Alteraciones del desarrollo por dificultades perinatales y la confusión con los trastornos del espectro autista. Revista de Neuropsicología 2010; 5: 4-9.
Cusick MF, Libbey JE, Fujijami RS. Molecular mimicry as a mechanism of autoimmune disease. Clin Rev Allergy Immunol 2012; 42: 102-11.
Boksa P. Effects of prenatal infection on brain development and behavior: A review of findings from animal models. Brain Behav Immun 2012; 24: 881-97.
Sanon NT, Desgent S, Carmant L. Atypical febrile Seizures, mesial temporal lobe epilepsy, and dual pathology. Epilepsy Research and Treatment. 2012; Available at: http://www.hindawi.com/journals/ert/ 2012/342928/abs/
Nickerson JP, Santy K, Lequin MH, Poretti A, Flippi CG, Huisman TA. Neuroimaging of pediatric intacraneal infection – part 2. TORCH, viral, fungal, and parasitic infections. Journal of Neuroimaging 2012; 22: e52-e63.
Berencsi III G (Ed) Maternal fetal transmission of human viruses and their influence on tumorigenesis. Hungary: Springer; 2012.
Karatas H, Gurer G, Pinar A, Soylemezqlu F, Guler G, Hascelik G, Akalan N, et al. Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV- 8 DNA by real time PCR in surgical resections materials of epilepsy patients with mesial temporal lobe sclerosis. J Neurol Sci 2008; 264: 151-6.
Volcy-Gómez M. Epilepsia del lóbulo temporal mesial: fisiopatología, características clínicas, tratamiento y pronóstico. Rev Neurol 2004; 38: 663-7.
Libbey JE, Sweeten TL, McMahon WM, Fujiami RS. Autistic disorder and viral infections. J Neurovirol 2005; 11: 1-10.
Singh V. Phenotypic expression of autoimmune autistic disorder (AAD): A major subset of autism. Ann Clin Psychiatry 2009; 21: 148-61.
Nicholson G, Haier J. Role of chronic bacterial and viral infections in neurodegenerative neurobehavioral, psychiatric, autoimmune and fatiguing illness: part 1. Brit J Med Practition 2009; 2: 20-8.