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2012, Number 2

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AbanicoVet 2012; 2 (2)

Micronucleus blood test as genotoxic biomarker

Cedano DA, Martínez GS, Escalera VF, Salgado MS, Carrillo DF, Macías CH, Peña PB

Language: Spanish
References: 33
Page: 43-54
PDF size: 324.65 Kb.


ABSTRACT

Among the multiple pollutants harm the genotoxic effect is expressed in various forms, such as teratogenicity, mutagenicity and carcinogenicity of course. Therefore, it is important to detect these compounds or harmful agents. There are several tests to identify genotoxic agents and the micronucleus test is the simplest and cheapest. It is possible to use it in vivo and in vitro, in plants and animals. Micronuclei are chromosome fragments or whole chromosomes that spontaneously or due to genotoxic agents, remain outside the nucleus during cell division. There are animals that spontaneously present micronucleated erythrocytes and with the effect of an inductor micronucleogénico this value increases, however, there are living beings who spontaneously and even with the effect of the inducer, do not present micronucleated erythrocytes; this is due to proper filter control of the hematopoietic system, which with increasing age it is more efficient.


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