medigraphic.com
ISSN 8541-3697 (Print)

2012, Number 2

<< Back Next >>

AbanicoVet 2012; 2 (2)

Function and mechanism of leptin in ruminants

Esperanza HT, Manuel MO

Language: Spanish
References: 28
Page: 33-42
PDF size: 264.06 Kb.


ABSTRACT

The objective of this research is to understand the mechanisms of leptin action in ruminants, since it is a hormone that allows determining properly the nutritional status of cattle. Leptin is a plasma protein formed by 167 amino acids and it is synthesized in adipose tissue; it provides information about the animal´s reserves of fat, acts as an efferent regulator of appetite, energy output, and the reproductive function. In addition leptin was positively correlated with the increase in body mass and affects the function and presence of other hormones such as insulin and growth hormone. These compounds collectively, reflect the adequate supply of nutrients with respect to their utilization; so, determining the concentration of leptin would determine the nutritional status of livestock accurately.


REFERENCES

  1. AGNEW RE, Yan T. 2000. The impact research on energy feeding systems for dairy cattle. Livest. Prod. Sci. 66:197-215.

  2. AMSTALDEN M, García MR, Williams SW, Stanko RL, Nizielski SE, Morrison CD, Keisler H, Williams GL. 2000. Leptine gen expression, circulating leptin, and luteinizing hormone pulsatily are acutely responsive to shorth-term fasting in prepubertal heifers: relationships to circulation insulin and insulin-like growth factor I. Biol. Reproduction. 63:127-133.

  3. ARAUJO-FEBRES O. 2005. Factores que afectan el consumo voluntarioen bovinos a pastoreo en condiciones tropicales. IX Seminario de pastos y forrajes. Facultad de Agronomía. Zulia.

  4. CARRO E, Senaris R, Considine RV, Casanueva FF, Dieguez C. 1997. Regulation of in vivo growth hormona secretion by leptin. Endocrinology. 138:2203-2206.

  5. CHILLIARD F, Bocquier F, Delavaud C, Guerre-Millo M, Bonnet M, Martin P, Faulconnier Y, Ferlay A. 1998. Leptin in ruminants: Effects of species, breed, adiposity, photoperiod, β-agonists and nutritional status. In: proc 1998 Cornell nutr. Conf. For Feed Manufacturers, Cornell University, Ithaca, NY. pp 65-74.

  6. CONSIDINE RV, Sinha MK, Heiman ML, Kriauciunas A, Stephen TW, Nyce MR, Ohannesian JP, Marcco CC, McKee LJ, Bauer TL, Caro JF. 1996. Serum inmunoreactive-leptin concentations in normal weigth and obese humans. N. Engl. J. Med. 334:292-295.

  7. DANIEL JA, Whitelock BK, Baker JA, Steel B, Morrison DD, Keisler DH, Sartin JL. 2002. Effect of body fat mass and nutriotional status on 24 hour leptin profiles in ewes. J. Anim. Scie. 80:1083-1089.

  8. DELAVAUD C, Ferlay A, Faulconnier Y, Boquier F, Kann G, Chilliard Y. 2002. Plasma leptin concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J. Anim. Scie. 80:1317-1328.

  9. EHRHARDT RA, Slepetis RM, Siegal-Willot J, Van Amburgh ME, Bell AW, Boisclair YR. 2000. Development of a specific radioinmunoassay to measure physiological changes of circulating leptin in cattle and sheep. J. Endocrinol. 166:519-528.

  10. HARDIE LJ, Guilhot N, Trayhurn P. 1996. Regulation leptin production in cultured mature white adipoyites. Horm. Metab. Res. 28:685-689.

  11. HERSOM J, Wettemann RP, Krehbiel CR, Horn GW, Keisler DH. 2004. Effect of live weigth gain of steers during wintwr grazing: III. Blood metabolites and hormones during feedlot finishing. J. Anim. Scie. 82:2059-2068.

  12. HOSSNER KL. 1998. Celular, molecular and physiological aspects of leptin potential applications in animal production. Canadian J. Of Anim. Scien. 78:463-472.

  13. HOUSEKNETCH KL, Clifton A, Matteri RL, Spurlock ME. 1998. The biology of Leptin: A Review. J. Anim. Scie. 76:1405-1420.

  14. HOUSEKNETCH KL, Portocarrero CP. 1998. Leptin and its receptors: regulators of whole body energy homeastasis. Domestics animal endocrinology. 15(6):457-475.

  15. KEISLER DH, Daniel JA, Morrison CD. 1999. Leptins role in nutritional status and reproductive function. J. Reprod. Fertil. (Suppl.) 54:425.

  16. LENTZ CA, Wettemann RP, White FJ, Rubio I, Ciccioli NH, Spicer LJ, Keisler DH, Payton ME. 2005. Influence of nutrint and body fat on concentrations of insulin-like growth factor-I, insulin, thiroxine, and leptin in plasma of gestating beef cows. J. Anim. Scie. 83:586-596.

  17. MEIKLE A, Kulcsar M, Chilliard Y, Febel H, Delavaud C, Cavestany D, Chilibroste P. 2004. Effect of parity and body condition at parturition on endicrine and reproductive parameters of the cow. Reproduction. 127:727-737.

  18. MORRISON CD, Daniel JA, Holmberg BJ, Dijiane J, Raver N, Gertler A, Keisler DH. 2001. Central infusion ofl leptin into well-fed and undernourished ewe lambs: Effects on feed intake and serum concentrations of growth hormone and luteinizing hormone. J. Endocrinol. 168.

  19. MOSTYN A, Keisler DH, Weeb R. 2001. The role of leptine in the transition from fetus to neonate. The proceedings of the nutrition society. 60(2):187-194.

  20. REYNOLDS CK, Benson JA. 2004. Gut peptides and feef intake regulations in lactating dairy cows. J. Anim. Sci. (suppl 1).

  21. SANSINACEA AS, Cerone SI, Zonco I. 2001. Serum leptin levels in cattle with different nutricional conditions. Nutrition Research 21:1045-1052.

  22. SORENSEN A, Adam CL, Findlay P. 2002. Leptin secretion and hipothalamic neuopeptide and receptor gene expression in sheep. American J. Phisiology. Regulatory, integrative and comparative phisiology. 2(4):1227-1235.

  23. STEPHENSON T, Budge T, Mosty H. 2001. fetal and neonatal adipose maturation: a primary site of citokine and citokine-receptor action. Biochemical Society transaction. 29(2):80-85.

  24. THOMAS MG, Enns RM, Hallford DM, Keisler DH, Obeidat BS, Morrison CD, Hernández JA, Bryabt WD, Flores R, López R, Narro L. 2002. Relationships of metabolic hormones and serum glucose to growth and reproductive develoment in performance tested angus, brangus, and bramhan bulls. J. Ani. Sci. 80:757-767.

  25. TSUCHIYA T, Nagao Y, Ozawa A, Matsumoto M, Sugahara K, Kubo T, Kato H. 1998. decrease of the obese gene expresión in bovine subcutaneous adipose tissue by fasting. Biosci. Biotechnoloy. Biochem. 62:2068-2069.

  26. VALDERRÁBANO JC, Gómez-Rincon J. Uriarte J. Relación entre la concentración de leptina plasmática y la respuesta inmune frente a hoemanchus contortus en el periparto ovino. Centro de investigación y Tecnología agroalimentaria. Gob. De Aragón, Zaragoza.

  27. ZHANG Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature (Lond) 372:425.

  28. ZIEBA AD, Amstalden M, Maciel MN, Keisler DH, Raver N, Gertler A, Williams GL. 2003. Divergent effects of leptin on leteinizing hormone and insuline secretion are dose dependent. Exp. Biol. Med. 228:325-330.




2020     |     www.medigraphic.com