López FG, Gil A, López-Ibor L, Boto GR, Serna CC

Language: Spanish
References: 63
Page: 470-479
PDF size: 263.96 Kb.

ABSTRACT

Cerebral arteriovenous malformations (cAVM) have vessels with mature walls and abnormal phenotypes. The high flow and hemodynamic stress predispose these vessels to additional vascular recruitment, arterializations of venous structures and gliosis of contiguous brain tissue. cAVM pathogenesis is attributed to the anomalous development of the cerebral vascular system, although the responsible factor or precipitating cause is still controversial. cAVM are dynamic lesions that may change in the course of the years as has been describe by neuroimagen studies. Although the molecular mechanisms inherent in their genesis are not well established, two systems of factors involved in the formation of the cerebral vessels has been identified in the endothelial cells: angiogenic grow factors and their receptors. This knowledge will allow to design better structured studies in order to find new evidences about the pathogenesis of cAVM, including new researches in the molecular field, that have repercussions for improving the management of this vascular malformations.

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