2012, Number 3
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Folia 2012; 6 (3)
Retrospective study of Mycosis fungoides during a five year period in 'Hermanos Ameijeiras' Hospital
Alvarado SCA, Collazo CSE, Hidalgo GD
Language: Spanish
References: 30
Page:
PDF size: 228.75 Kb.
ABSTRACT
Mycosis Fungoide (MF) accounts for 50 % of all cutaneous T-cell lymphomas, the
incidence of the disease has increased over the last decade in our centre. Our goal was
to characterize the behavior of MF for the patients treated from 2006 to 2010 at
Hermanos Ameijeiras Hospital from Havana, Cuba. A retrospective study was
conducted considering demographic and clinical variables. The Statistical method used
was the Percentage Method.
Results: The size of the sample was 101 patients, the
average age was 53.1 years old, the difference between the number of female and
male patients was not significant, most patients were classified as Hispanic or
Caucasian. According to the TNBM classification, we found 88,1% of patients with early
stage MF. The objective response to treatment was 61.4 %, 26.7 % of patients
remained stable, 5.9 % showed progression of the disease and 5.9 % died, from which
83.3 % died of the disease. The five year survival rate was 87 %.
Conclusions:
Results for demographic variables were similar to those found in literature. The classic
type and the early stages of the disease were predominant. No factors affecting the
debut and progression of the disease were identified. The deaths were related to the
later stages of the disease. The three year survival rate was high.
REFERENCES
Duvic M; Sherman ML, Wood GS, Kuzel TM, Olsen E, Foss F, et al. A phase II openlabel study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides. J Am Acad Dermatol, 2006;55(5):807-13
Fernandez JM, Armario JC, Conde T, Pujol R, Rodriguez J. Linfomas Cutâneos. 1ra Ed. Servicio de Publicaciones de La Universidad de Cádiz; 2007. p.67-87.
Maleki Z, Azmi F. Mycosis Fungoides of the True Vocal Cord:A Case Report and Review of the Literature. Arch of Iran Med Int 2010; 15(5):429-421
CampoE, SwerdlowSH, HarrisN L, PileriS, SteinH, Jaffe E S. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011; 117(19): 50195032.
Olsen E, Vonderheid E, Pimpinelli N, Willemze R, Kim Y, Knobler R, et al. Revision to the staging and classification of mycosis fungoides and Sésary syndrome: a proposal of the International Society for Cutaneos Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organitation of Treatment of Cancer (EORTC).Blood 2007; 110(6): 1713-1724
Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105(6): 3768-3786.
Duvic M, Olsen E: International Society of Cutaneous Lymphoma (ISCL) and the European Organization of Research and Treatment of Cancer (EORTC) revisions to the staging and classification of mycosis fungoides and Sézary syndrome. The Internet J Dermatol. 2009 CME-Certified Activity
Ball E, Martin R. Micosis fungoides. Estudio clínico prospectivo en una cohorte de pacientes venezolanos. Dermatol Venezolana 2007; 45: (3): 4-14
Weder P, Anliker M, Itin P, Bargetzi M. Familial Cutaneous Mycosis Fungoides: Successful Treatment with a combination of Gemcitabine and Alemtuzumab Dermatology 2004; 208: 281-283.
Abeldaño A, Azcune R, Consenso Linfomas Cutáneos Primarios SAD [en línea] [www.sad.org.ar/revista.1/05/2007]. ISSN 1669-1636.
Morales-Suárez MM, Olsen J, Johancen P, Kaerlev L, Guénel P, Arveux P, et al. Occupational Sun Exposure and Mycosis Fungoides: A European Multicenter CaseControl Study. J Occup Environ Med. 2006;48:390393.
Bradford PT, Devesa SS, Anderson WF, Toro JR. Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. Blood 2009;113(21):50645073.
Díaz T , Céspedes A, Laguna L, Céspedes Y. Micosis Fungoide. Folia Dermatol Cuba 2010; 4(3): [en línea] http://bvs.sld.cu/revistas/fdc/vol4_3_10/fdcsu310.htm
Beltrán B, Paredes A, Moisés C, Sanchez G, Riva L, Hurtado F, Cotrina E, Salas R. Tratamiento del linfoma cutáneo de células T con bexaroteno a dosis bajas en combinación con fototerapia o interferon alfa: comunicación de ocho casos tratados en el Hospital Edgardo Rebagliati Martins, 2003-2007, Lima, Perú. Acta Med Per 2008; 25(4):232-235
Vidarte G, Alvarez G, Micosis fungoide en estadio en placa. Dermatol Peru 2008;18(2): 118-121
Beirana PA, Gutiérrez OT, Domínguez GA, Navarrete FG, Ramos GJA. Micosis fungoide en edad pediátrica. Rev Cent Dermatol Pascua. 2006;15(3):149-143
Abudinén G, Castet A, Chassin-Trubert AM. Mycosis fungoides: a case report. CIMEL 2010; 15(1): 34-37
Sander CA, Flaig MJ, Jaffe ES. Cutaneous manifestations of Lymphoma: clinical guide based on the WHO classification. Clin Lymphoma 2001;2:86-100.
Fischmann AB, Bunn Jr PA, Gruccion JG, Mathews MJ, Minna JD. Exposure to chemical, physical agents, and biologic agents in mycosis fungoides and Sezary syndrome. Cancer Treat Rep 1979, 63, 591-596.
Morales-Suarez MM, Olsen J, Kaerlev L, Guénel P, Arveux P, Wingren G. Are alcohol intake and smoking associated with mycosis fungoides? A European multicentre case-control study. Eur J Cancer 2001;37:392-397
Trujillo IA, Collazo S, Rodriguez MA, Arteaga E, Blanco O, Arguello J. Liquen Plano lineal secundario a interferón alfa recombinante. Dermatol Peru 2008; 18 (4):350-354
Latkowski Jo, Helad P. Linfomas cutáneos de linfocitos T. 6ª edición, Editorial Panamericana, Tomo II, EUA, 2005: 1736-1759.
Collazo SE, Pesant O, Rodríguez MA, García R. Comportamiento de la micosis fungoide hipopigmentada en pacientes del Hospital Hermanos Ameijeiras, 1996-2006. Folia Dermatol Cuba 2007;1(1): [en línea]http://bvs.sld.cu/revistas/fdc/vol1_01_07/fdc07107.htm
Van Doorn R, Van Hesele CW, Van Voorst PC. Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients. Arch Dermatol 2000;136:504-10.
Gómez E. Factores clínicos de progresión tumoral y supervivencia en linfomas cutáneos de células T (Micosis fungoide-Síndrome de Sézary) [tesis]. Madrid (Es). Universidad Complutense de Madrid; 2002
Ku, L Lo, K. Mycosis Fungoides a retrospective study of 40 cases in Hong Kong. Int J Dermatol 2005; 44(2): 15-20
Metyer N, Paul C, Misery L. Pruritus in cutaneous T- cell Lymphomas: Frequent, often severe and difficult to treat. Acta Derm Venereol 2010;90: 12-17
Demierre MF, Gans S, Jones J, Miller DR. Significant impact of cutaneos T-cell lymphoma on patient's quality of life. Cancer 2006;107: 2504-2511
Duvic M. Tratamiento actual del Linfoma cutáneo de células T. Dermatol Online J 2001;7(1):3.
Moredo E, Moreira M, Pérez A. Uso de los interferones en Dermatología: experiencia con el alfa-interferón en la micosis fungoide. Rev Cubana Farm 2004;38(2) [En línea]. http://bvs.sld.cu/revistas/far/vol38_2_04/far07204.htm