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Academia Mexicana de Neurología, A.C.

2009, Number 6

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Rev Mex Neuroci 2009; 10 (6)

Intracranial aneurysms: molecular and genetic aspects related to their origin and development

Guerrero-Muñiz S, Zárate-Méndez AM, Pérez RJC, Chima-Galán MC, García-Ortiz L, Gutiérrez-Salinas J

Language: Spanish
References: 35
Page: 453-458
PDF size: 56.04 Kb.


ABSTRACT

In 80% of the cases of spontaneous subarachnoid hemorrhage, the etiologic factor is the break of an intracranial aneurysm which is presented with an incidence from 6 to 33 cases/100,000 annually, with greater frequency in women than in men.
At present, it is known that biochemical and molecular factors are involved in the development and formation of an aneurysm. Some of the physiopathologic mechanisms that intervene in the formation of an aneurysm are the following: A) factors that alter the architecture of the vascular structure (such as metalloproteinasas that degrade the components of vascular wall, like collagen, stromelisine, etc.), and B) molecules involved in the mechanism related to local inflammation process (interleukines, cytocines, etc.). This latter can generate oxygen or nitrogen reactive species which act weakening the vascular wall. In an attempt to understand the genetic mechanisms that intervene in the development of the intracranial aneurysms, molecular studies have contributed in establishing a probable association among the presence of the aneurysms and the expression of gens that function like specific molecular markers which would be very useful as early measures of diagnosis in the general population. In the present work, a brief revision and description of the biochemical, molecular and genetics mechanisms that intervene in the genesis and development of intracranial aneurysms is carried out.


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