Epidemiology of xanthogranulomatous cholecystitis

Luis Eduardo Cárdenas-Lailson; Bertha Torres-Gómez; Salvador Medina-Sánchez; Juan Manuel Mijares-García; Jorge Hernández-Calleros

2005, Number 1

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Cir Cir 2005; 73 (1)

Epidemiology of xanthogranulomatous cholecystitis

Cárdenas-Lailson LE, Torres-Gómez B, Medina-Sánchez S, Mijares-García JM, Hernández-Calleros J

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Language: Spanish
References: 19
Page: 19-23
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ABSTRACT

Objective: In order to study patients with a diagnosis of xanthogranulomatous cholecystitis (XCG), we analyzed their demographics, epidemiology and clinical data.
Material and methods: We analyzed the clinical records of patients with a histopathologic diagnosis of XGC during a period of 6 years, obtaining demographic, epidemiologic and clinical data.
Results: Of a total of 1425 cholecystectomies performed between January 1991 and December 1996, we found 35 cases of XGC (2.4%). Twenty six (74%) were women (median age: 44 years), 60% were from a low socioeconomic group, 34% had a history a alcoholism and smoking, and 25 patients (71%) had a blood type of O positive. Thirteen patients (37%) presented obstructive jaundice, 11 had dilatation of the choledocus and were treated with ERCP. Of the 35 cholecystectomies, 15 were urgent and 20 elective. Eight were operated laparoscopically and two were converted because of firm adhesions. We had five transoperative complications.
Discussion: Pre-operative XGC diagnosis is difficult, often mistaken for gallbladder cancer. The incidence in our sudy (2.4%) is higher than reports in industrialized countries (0.7–1.8%), with a female predominance. The most frequent clinical presentation is that of chronic cholecystitis, but we found a high percentage of patients with obstructive jaundice. We had 0% mortality and 26% morbidity, and no association was found between XGC and gallbladder cancer.

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