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ISSN 0188-9796 (Print)

2012, Number 3

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Rev Endocrinol Nutr 2012; 20 (3)

Predisposing factors to diabetes mellitus in patients with obstructive sleep apnea

Portillo-Sánchez P, Ramírez-Rivera A, Villarreal-Coindreau G, Valdez-López HG, Villela-Martínez L

Language: Spanish
References: 19
Page: 107-112
PDF size: 187.45 Kb.


ABSTRACT

Background and objectives: Obstructive sleep apnea is characterized by intermittent airway obstruction during sleep, that results in apnea or hypopnea that trigger an activation of various hormonal systems. Hispanic patients with obstructive sleep apnea have a higher prevalence of diabetes that is associated with the severity of the condition. Objective: To estimate the prevalence of diabetes and prediabetes in patients with obstructive sleep apnea. Material and methods: We retrospectively evaluated the charts of 102 patients with obstructive sleep apnea, documented by polysomnography who were seen between June 1998 and March 2012. Anthropometric, clinical and biochemical data was obtained. The frequency of diabetes and other abnormarlities of glucose metabolims were established and in some cases, the insulin resistance index was calculated by means of the HOMA method. We sought correlations between the presence of obstructive sleep apnea and abnormalities of glucose metabolism. Results: Of the 122 patients evaluated with polysomnography, 13.1% had mild obstructive sleep apnea, 12.3% had moderate obstructive sleep apnea and 75.6%were classified as having severe obstructive sleep apnea. Diabetes as a new diagnosis was present in 10 patients (8.2%), where as glucose intolerance was found in 55 (45%), the remaining patients did not show any abnormalities in glucose metabolism. The median insulin resistant index by HOMA was 5.73. The presence of diabetes was positively associated with body mass index. The most commonly associated comorbidities were cardiovascular disease, chronic obstructive pulmonary disease and hypothyroidism. Conclusions: We did not find a direct association between diabetes and prediabetes and obstructive sleep apnea, however, obese patients with obstructive sleep apnea tended to have a higher frequency of abnormalities in glucose metabolism.


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