Efficiency of the surgical treatment in patients with refractory epilepsy

Iris González Orizaga; Manuel Hernández Salazar; Silvia García; Noel Plascencia Álvarez; Sergio Sauri Suárez; Cuauhtémoc Gil Ortiz; Jorge Varela Blanco; Josefina Hernández Cervantes; Oscar Meneses Luna; Francisco Valencia Granados; Martha Ochoa Madrigal; Erika Meza Dávalos; Aura Moreno Bernal; Tomás Alarcón Aviles; Bernardo Hernández Curiel; Juan Arriaga Ramírez; Clara Gutiérrez López; Francisco Juárez Cosmes; Bertin Martínez Silva; Lilia Núñez Orozco

2008, Number 6

Rev Mex Neuroci 2008; 9 (6)

Efficiency of the surgical treatment in patients with refractory epilepsy

González OI, Hernández SM, García S, Plascencia ÁN, Sauri SS, Gil OC, Varela BJ, Hernández CJ, Meneses LO, Valencia GF, Ochoa MM, Meza DE, Moreno BA, Alarcón AT, Hernández CB, Arriaga RJ, Gutiérrez LC, Juárez CF, Martínez SB, Núñez OL

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ABSTRACT

Introduction: 20 to 30 percent of patients with epilepsy are refractory, but many of them improve or become free of seizures after surgery treatment. Objective: To investigate the improvement after surgery in patients with refractory epilepsy in our reference center, which recently began with this procedure, and compare our results with the obtained in other hospitals. Methods: We analyzed a total of 18 patients with focal and generalized refractory epilepsy, applying comparative analysis in terms of the number of seizures before and after surgery, using Wilcoxon test. Results: 10/18 patients (55.6%) were female and 8 (44.4%) male, with ages ranging from 17 to 48 years and an average of 31; age of onset of epilepsy from 6 months to 29 years, average 9.6 years. The average number of seizures was 79.2 per month before surgery and 20.6 after surgery. 11 patients (61.1%) had less than 6 seizures on average per month, and 3 (16.7%) of them were free of seizures (T of Wilcoxon p = 0.001). Conclusions: The vast majority of studies in the literature show a reduction in the number and intensity of seizures after surgery. In our series the results are encouraging, and led to the development of a programme within our institution for the surgical treatment of epilepsy.

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