2007, Number 5
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Rev Mex Neuroci 2007; 8 (5)
Neuropsychological study of inhibition in Parkinson’s disease patients
Pedroso II, Bringas ML, Casabona E, Salazar S, Álvarez L
Language: Spanish
References: 41
Page: 506-511
PDF size: 57.88 Kb.
ABSTRACT
Aron et al. demonstrated the critical role of right inferior frontal cortex in suppressing an already initiated manual response, yet
it is unclear how this inhibitory function is implemented in the motor system. Mink suggested that the basal ganglia and specially
the subthalamic nucleus, could play an important role because it suppresses the “direct” fronto-striatal pathway that is activated
by response initiation. We want to study the inhibition response during the initiated response performed by Parkinson´s disease
(PD) patients in order to find the appropriate paradigm for further activation studies using functional magnetic resonance. Two
groups were selected: 10 PD patients (without surgical treatment) and a control group (healthy subjects) with similar age and
educational level. Subjects performed a computerized test, Stop Signal Task, which examines the motor inhibiton control,
measuring the latency of inhibitory process to stop the initiated response. Two arrows, with opposite directions appear at the
screen and the subject will press the similar key on the keyboard. First, we calculate the typical reaction time for each subject
in the GO condition. Then, the test was conducted, introducing the STOP signal (25% of 500 trials). Results showed differences
between groups because the mistakes and reaction time on the GO condition were higher in the PD patients.
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