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Academia Mexicana de Neurología, A.C.

2007, Number 5

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Rev Mex Neuroci 2007; 8 (5)

Effects of the centrotemporal epileptiform discharges on the cortical language representation

Andrade MR, de la Cruz TA, García EA, Machado RA, Herrera JLF, Arteché PM

Language: Spanish
References: 38
Page: 472-480
PDF size: 88.49 Kb.


ABSTRACT

Introduction: Benign Childhood Epilepsy with centro-temporal spikes is an idiopathic partial epileptic syndrome accepted by ILAE since 1989. Cognitive impairment may be observed in large series of patients with this syndrome. The effect of centrotemporal spikes lateralization on cerebral organization of language function has not been study entirely. Objective: To determine if the spike localization could modified cortical language organization depending of the time with seizures and whether interictal SPECT images show hypoperfusion areas related with cortical language areas. Patients and method: Right-handed children were assigned in one of three groups matched by sex and age. The first was for healthy children, the second group was for children with left cortical spikes and the last one for children with right cortical spikes. We assessed the functional reorganization of cortical language areas applying the cognitive paradigms described by Cook and Kinsbourne. Cerebral blood flow was assessed in children with seizures, cognitive déficit and left cortical spikes. Results: The study included a total of 25 children with seizures and 336 healthy children. 14 of 25 children had spikes located in the right side, the other 11 had spikes on the left cortical side. Functional language reorganization was found after 10 months of seizures onset. We reported cortical hipoperfused areas related with epileptic focus side (p = 0.01). Conclusion: Inhibition on epileptic focus side is associated with a bihemispheric cortical language representation. These features seem to be related with the time of seizures onset.


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