Rodríguez ML, Álvarez GE, Serra VY, Alessandrini GR

Language: Spanish
References: 10
Page: 539-543
PDF size: 52.48 Kb.

ABSTRACT

Introduction: The existent programs of treatment are recognized from the secondary neurological sequels to an stroke that has as objective to improve neurological handicap, functional incapacity and quality of life. The identification of factors recovery presage contributes to guide the treatment. The plasmatic uric acid has been identified as potent neuroprotector in stroke. Theoretically, the patients with hyperuricemia can be favored with a better evolution. Material and methods: We carried out a study of analytic, prospective type, with 77 patients, with secondary chronic sequels to Cerebrovascular Illness. It were used as variables the demographic data, stroke type, uric acid value to the entrance, Barthel Index (BI). The functional incapacity of the patients was evaluated, considering severe incapacity to those with BI ‹ 60 points, moderate incapacity with BI among 60 and 90 points, and slight incapacity with BI › 90 points. The Global Functional Gain was calculated as the difference between the final BI and initial. The data were captured on an on-line database. The treatment denominated Program of Neurological Restoration; it was carried out, in regime of hospitalization, during 28 days. Descriptive statistic was used to characterize the study universe, using stockings for quantitative variables and percents for qualitative variables. To analyze the functional recovery and the influence of the uric acid, it was used t-Student, multiple regression test and the Spearman Rank Correlations. Results: The functional recovery of the study universe was significant with a Global Functional Gain of 8.01 points. We don’t found influence of the value AU on the functional recovery. Conclusions: The Program of Neurological Restoration is effective for the functional recovery of the patients with sequels for stroke. The plasmatic value of the uric acid doesn’t constitute a factor recovery presage in patient chronic.

REFERENCES

1. Bonita R. Epidemiology of stroke. Lancet 1992; 339: 342-4.

2. Sánchez BI, Ochoa SC, Izquierdo SM. Pronóstico de recuperación funcional en personas supervivientes de un ictus. Rehabilitación (Madr) 2000; 34(6): 412-22.

3. Chamorro A, Planas AM, Muner DS, Deulofeu R. Uric acid administration for neuroprotection in patients with acute brain ischemia. Med Hypotheses 2004; 62(2): 173-6.

4. Amaro S, Soy D, Obach V, Cervera A, Planas AM, Chamorro A. A Pilot Study of Dual Treatment with Recombinant Tissue Plasminogen Activator and Uric Acid in Acute Ischemic Stroke. Stroke 2007.

5. Torres JR, et al. Disfunción endotelial e hiperuricemia: Papel de la enzima xantino oxidasa. Rev Clin Esp 2002; 202(10): 549-51.

6. Luo CX, Zhu XJ, Zhou QG, Wang B, Wang W, Cai HH, et al. Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. J Neurochem 2007.

7. Baztán JJ, Pérez-Martínez DA, Fernández-Alonso M, Aguado-Ortego R, Bellando-Álvarez G, de la Fuente-González AM. Factores pronósticos de recuperación funcional en pacientes muy ancianos con ictus. Estudio de seguimiento al año. Rev Neurol 2007; 44(10): 577-83.

8. Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS. Stroke. Neurologic and functional recovery the Copenhagen Stroke Study. Phys Med Rehabil Clin N Am 1999; 10: 887-906.

9. Nishida AP, Amorim M, de Zilio M, Inoue MM, Aoki E. Índice de Barthel e do Estado Funcional de pacientes pós acidente vascular cerebral em programa de fisioterapia / Barthel Index and Fuctional Status of patients after stroke in a physical therapy program. Salusvita 2004; 23(3): 467-88.

10. De Wit L, Putman K, Schuback B, Komárek A, Angst F, Baert I, Berman P, et al. Motor and Functional Recovery After Stroke. A Comparison of 4 European Rehabilitation Centers. Stroke 2007.