2012, Number 4
<< Back Next >>
Rev Cubana Hematol Inmunol Hemoter 2012; 28 (4)
Quality of life in patients with chronic lower limb ischemia treated with adult stem cells
Alfonso-Simón A, Feísto-Castex T, Llopiz-Casanova L, Hernández-Ramírez P
Language: Spanish
References: 13
Page: 398-403
PDF size: 122.75 Kb.
ABSTRACT
An assessment of the quality of life in 45 patients older than 60 years with chronic
arterial ischemia of the lower limbs was conducted. Out of them, 34 had severe
ischemia, and 11 had ischemic diabetic foot, as well as severe injuries. All had been implanted mononuclear cells in the affected lower limb, which derived from the
bone marrow, and mobilized to the peripheral blood with granulocyte colony
stimulating factor. For assessing quality of life, SF-36 questionnaire was selected,
which focuses its content on two areas: functional status and emotional well being.
All cases showed poor quality of life before implantation. Improvement was evident
on the sixth month after cell therapy. Cases with a year of evolution had achieved
good quality of life. Most of the patients, who had successful outcomes, could join
social activities and employment, which was previously not possible.
REFERENCES
Morales-Calatayud FJ. Introducción a la Psicología de la Salud. México: Unison; 1997.
Lugones M. Algunas consideraciones sobre la calidad de vida. Rev Cubana Med Gen Integr. 2002;18:287-9.
Walter SR, Rosser RM. Quality of life: Assessment and Application. Lancaster: MTP Press Ltd.; 1987.
Morgan M, Crayford T, Murrin B, Fraser S. Developing the vascular quality of life questionnaire: a new disease-specific quality of life measure for use in lower limb ischemia. J Vasc Surg. 2001 Apr;33:679-87.
Yan BP, Lau JY, Yu CM, Au K, Chan KW, Yu DS, et al. Chinese translation and validation of the Walking Impairment Questionnaire in patients with peripheral artery disease. Vasc Med. 2011 Jun;16(3):167-72.
Chong PF, Garratt AM, Golledge J, Greenhalgh RM, Davies AH. The intermittent claudication questionnaire: a patient-assessed condition-specific health outcome measure. J Vasc Surg. 2002 Oct;36(4):764-71.
Mehta T, Venkata Subramaniam A, Chetter I, McCollum P. Disease-specific quality of life assessment in intermittent claudication: review. Eur J Vasc Endovasc Surg. 2003 Mar;25(3):202-8.
Hernández P, Artaza H, Díaz AJ, Cortina LD, Lam RM, Pol N, et al. Autotrasplante de células madre adultas en miembros inferiores con isquemia crítica. Experiencia en Cuba. Rev Esp Invest Quirúrg. 2007;10:204-11.
Ware JE, Kosinski M, Keller SD. SF 36 physical and mental health summary scales: a users manual. 3 ed. Boston: The Health Institute, New England Medical Center; 1994.
Burk RK, Testori A, Oyama Y, Rodríguez HE, Yaung K, Villa M, et al. Autologous peripheral blood CD133+ cell implantation for limb salvage in patients with critical limb ischemia. Bone Marrow Transplant. 2010 Jan;45(1):111-6.
Gallegos-Carrillo K, García-Peña C, Durán-Muñoz CA, Flores YN, Salmerón J. Relationship between social support and the physical and mental wellbeing of older Mexican adults with diabetes. Rev Invest Clin. 2009 Sep-Oct;61(5):383-91.
Cabrera ME, Agostini MT, Victoria CR, López R. Calidad de vida y trabajo comunitario integrado. Sistema de indicadores para la medición de la calidad de vida. Reporte de investigación. La Habana: Centro de Investigaciones Psicológicas y Sociológicas; 1998.
Hoshino J, Ubara Y, Hara S, SogawaY, Suwabe T, Higa Y, et al. Quality of life improvement and long-term effects of peripheral blood mononuclear cell transplantation for severe arteriosclerosis obliterans in diabetic patients on dyalisis. Circ J. 2007 Aug;71(8):1193-8.