Rosado GFM, Núñez FFÁ, Ruiz EA, Rojas RL, Andrade MR, Kanaobana K, Polman K

Language: Spanish
References: 22
Page: 249-257
PDF size: 77.52 Kb.

ABSTRACT

Introduction: the epilepsy is an alteration of the central nervous system (CNS) which roughly affects 50 millions of persons worldwide; almost 85 % of them live in developing countries. Approximately 20 % of epilepsies are difficult to control or they are called refractory epilepsies. Taking into account the lack of Cuban reports about the behavior of intestinal parasitic infections in these patients, it was decided to carry out this research study in a group of epileptic patients with unknown etiology, from the Institute of Neurology and Neurosurgery in Havana.
Objectives: to determine the prevalence and the clinical manifestations of intestinal parasitic infections, and the possible association of these infections with epilepsy refractory to the antiepileptic drugs.
Methods: a questionnaire was applied and one fecal sample was taken per patient. Various parasitological techniques were implemented, including direct wet mount, Willis concentration technique, and Kato Katz quantitative procedure.
Results: of the studied epileptic patients, 41.7 % were found infected by parasites or commensals, and diarrhea was the only clinical characteristic that prevailed in parasitized persons. The group of patients without epilepsy refractory to antiepileptic drugs had higher frequency of infections with commensal or protozoa with controversial pathogenicity.
Conclusions: a high frequency of intestinal parasitic was observed in epileptic patients although just one sample was taken per person, and the protozoal infections prevailed over the helminthic infections. The comparison of the results from the group of patients with refractory epilepsy to antiepileptic drugs and the group without this condition may indicate a possible effect of this treatment over infections with commensal protozoa or of controversial pathogenicity. All this supports the continuity of studies about intestinal parasitic infection and their potential influence on antiepileptic treatment or vice versa.

REFERENCES

1. Sampieri A, Morales-Ramírez A, Calderón-Guzmán D, Carmona-Aparicio L. Últimos avances en la clasificación de las crisis epilépticas. Acta Pediatr Mex. 2011;32(2):122-4.

2. Carod-Artal. Causas tropicales de epilepsia. Rev Neurol. 2009;49(9):475-82.

3. Bloom DE. 7 billion and counting. Science. 2011;333(6042):562-9.

4. Maya CM. Epilepsia. La Habana: Editorial Ciencias Médicas; 2010. p. 62, 372-3.

5. Fabelo JR, Martín L, Iglesias S. La aceptación de la enfermedad y la adhesión al tratamiento en pacientes con epilepsia. Rev Cubana Salud Pública. 2011;37(1): 3-11.

6. Valdivia Álvarez I, Borges GA. Epilepsia de difícil control en Pediatría. Nuevas drogas Antiepilépticas. Rev Cubana Pediatr. 2005[citado 20 Abrl 2012];77(3-4). Disponible en: http://bvs.sld.cu/revistas/ped/vol77_3_05/ped08305.htm

7. Eslava JA, Salgado I, Quintero RA. Parasitismo intestinal y absorción de anticonvulsivantes. Repert Med Cir. 2007;16(4):181-4.

8. Eslava JA. ¿Influye el parasitismo intestinal sobre la absorción de anticonvulsivantes? Univ Méd. 1984;26(4):261-2.

9. Botero D, Restrepo M. Parasitosis humanas. 4ta ed. Medellín, Colombia: Corporación para Investigaciones Biológicas; 2003. p. 455-83.

10. Ferrer E. Teniasis/cisticercosis: del diagnóstico convencional al diagnóstico molecular. SALUS. 2007;11(1):57-61.

11. Cartwright CP. Utility of multiple- stool- specimen ova and parasite examinations in a high- prevalence setting. J Clin Microbiol. 1999;37(8):2408-11.

12. Pérez M. Prevalencia de Blastocystis hominis según estaciones de año en escolares de Ciudad de La Habana [Tesis de Especialista de I Grado en Microbiología]. La Habana: Instituto de Medicina Tropical "Pedro Kourí"; 2009.

13. Rojas L, Núñez F, Aguiar PH, Silva LC, Álvarez D, Martínez R, et al. Segunda encuesta nacional de infecciones parasitarias intestinales en Cuba, 2009. Rev Cubana de Med Trop. 2012;64(1):15-21.

14. Herrera R, Córdoba Y, Ageitus A. Parasitismo intestinal en adultos: área de salud San Andrés, Holguín, diciembre 1999 a diciembre 2002. Correo Científico Médico de Holguín 2004[citado 20 Abrl 2012];8(1). Disponible en: http://www.cocmed.sld.cu/no81/n81ori4.htm

15. Vázquez A, González C, Sánchez J, Menéndez AA. Distribución y características ecológicas de moluscos fluviales de interés médico en la provincia Santiago de Cuba. Rev Cubana Med Trop. 2011;63(1):58-63.

16. Baldi F, Bianco MA, Nardone G, Pilotto A, Zamparo E. Enfermedades diarreicas agudas. World J Gastroenterol. 2009;15(27):3341-8.

17. Campos JM, Sánchez V, Villalba José D'A. Entamoeba histolytica y su relación huésped-parásito. Enf Inf Microbiol. 2011;31(2):63-70.

18. Tan KSW. New insights on classification, identification, and clinical relevance of Blastocystis spp. Clin Microbiol Rev. 2008;21(4): 639-65.

19. Salinas JL, Vildozola H. Infección por Blastocystis. Rev Gastroenterol Perú. 2007;27(3):264-74.

20. Escobedo AA, Cañete R, Núñez FA. Intestinal protozoan and helminth infections in the Municipality San Juan y Martinez, Pinar del Rio, Cuba. Trop Doct. 2007;37(4):236-8.

21. Devera R, Angulo V, Amaro E, Finali M, Franceschi G, Blanco Y, et al. Parásitos intestinales en habitantes de una comunidad rural del Estado Bolívar, Venezuela. Rev Biomed. 2006;17(4):259-68.

22. Ministerio de Salud Pública. Formulario Nacional de Medicamentos. La Habana: Editorial Ciencias Médicas; 2006. p. 72-91.