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2013, Number 1

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Rev Cubana Hematol Inmunol Hemoter 2013; 29 (1)

Meta-analysis: prevalence of iron deficiency in systematic blood donors and its association with gender

Mantilla-Gutiérrez CY, Cardona-Arias JA

Language: Spanish
References: 40
Page: 59-72
PDF size: 228.84 Kb.


ABSTRACT

Introduction: the systematic blood donation and female gen derenhance the development of iron deficiency causing in adequate supply of blood and commitment to the health of the donor. Few studies have evaluated the interaction between gender and type of donor that is required for integrating the information.
Objective: to determine the prevalence of iron deficiency in systematic blood donors and analyze its association with gender, from a meta-analysis.
Methods: a comprehensive and reproducible search of the literature in 7 databases. Over all and specific prevalence by genderand donor type were determined. Prevalence ratios and odds were calculated. Meta-analytic analysis under the random effects model were performed.
Results: a sample of 9 260 donors, first time and systematic donors, of both sexes between 18 and 67 years old,was obtained. The overall prevalence of iron deficiency was 12,25 % (95 % CI: 11,57 % to 12,92 %); women had 98 % higher prevalence of the event than men and were 3,03 times more frequent in systematic donors than those in the first time. The overall probability of developing deficiency in systematic donors was 4,28 times higher (95 % CI2, 65 to 6,89) than the value observed in first time donors. The prevalence found was similar to that obtained in high-risk groups such aspregnant women, being higher in women and in systematic donors, factors that interact to enhance the like lihood of developing iron deficiency. It is necessary to focus on the health care of the donor to comply with ethical and political issues.


REFERENCES

  1. DeBenoist B, McLean E, Egli I, Cogswell M, eds. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. 2008. Disponible en: http://whqlibdoc.who.int/publications/2008/9789241596657_eng.pdf

  2. Speedy J, Minck SJ, Marks DC, Bower M, Keller AJ. The challenges of managing donor haemoglobin. ISBT Sci Ser. 2011 Dec;6(2):408-15.

  3. Bianco C, Brittenham G, Gilcher RO, Gordeuk VR, Kushner JP, Sayers M, et al. Maintaining iron balance in women blood donors of childbearing age: summary of a workshop. Transfusion. 2002;42(6):798-805.

  4. Badami KG, Taylor K. Iron status and risk-profiling for deficiency in New Zealand blood donors. N Z Med J. 2008;121(1274):50-60.

  5. Maghsudlu M, Nasizadeh S, Toogeh GR, Zandieh T, Parandoush S, Rezayani M. Short-term ferrous sulfate supplementation in female blood donors. Transfusion. 2008;48(6):1192-7.

  6. Coy Velandia LS, Castillo Bohórquez M, Mora AI, Munevar A, Yamile Peña Y. Características hematológicas de donantes de sangre de Bogotá, DC, Colombia (2.600 m). Revista Med de la Facultad de Medicina. 2007;15(1):40-7.

  7. Hillgrove T, Moore V, Doherty K, Ryan P. The impact of temporary deferral due to low hemoglobin: future return, time to return, and frequency of subsequent donation. Transfusion. 2011;51(3):539-47.

  8. World Health Organization; Centers for Disease Control and Prevention. Assessing the iron status of populations. 68 April 2004. Disponible en: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/97 89241596107/en/index.html

  9. Gonçalez T, Sabino EC, Chamone DF. Trends in the profile of blood donors at a large blood center in the city of São Paulo, Brazil. Rev Panam Salud Pública. 2003;13(2-3):144-8.

  10. Rafael P, Godoy P, Vidal Escudero J. Perfil socio-demográfico del donante de sangre del Hospital Nacional Cayetano Heredia-Lima: una comparación entre 1988 y 1994. Rev Med Hered. 2000;11(2):42-7.

  11. Cable RG, Glynn SA, Kiss JE, Mast AE, Steele WR, Murphy EL, et al. Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study. Transfusion. 2011;51(3):511-22.

  12. Cancado RD, Chiattone CS, Alonso FF, Langhi Junior DM, Alves Rde C. Iron deficiency in blood donors. Sao Paulo Med J. 2001;119(4):132-4.

  13. Mittal R, Marwaha N, Basu S, Mohan H, Kumar AR. Evaluation of iron stores in blood donors by serum ferritin. Indian J Med Res. 2006;124(6):641-6.

  14. Nadarajan VS, Eow GI. Anaemia and iron status among blood donors in a blood transfusion unit in Malaysia. Malays J Pathol. 2002;24(2):99-102.

  15. Nadarajan VS, Sthaneshwar P, Eow GI. Use of red blood cell indices for the identification of iron deficiency among blood donors. Transfus Med. 2008;18(3):184-9.

  16. Shahshahani HJ, Attar M, Yavari MT. A study of the prevalence of iron deficiency and its related factors in blood donors of Yazd, Iran, 2003. Transfus Med. 2005;15(4):287-93.

  17. Terada CT, Santos PCJL, Cancado RD, Rostelato S, Lopreato FR, Chiattone CS, et al. Iron deficiency and frequency of HFE C282Y gene mutation in Brazilian blood donors. Transfus Med. 2009;19(5):245-51.

  18. Røsvik AS, Ulvik RJ, Wentzel-Larsen T, Hervig T. The effect of blood donation frequency on iron status. Transfus Apher Sci. 2009;41(3):165-9.

  19. Abdullah SM. The effect of repeated blood donations on the iron status of male Saudi blood donors. Blood Transfus. 2011;9(2):167-71.

  20. Badar A, Ahmed A, Ayub M, Ansari AK. Effect of frequent blood donations on iron stores of non anaemic male blood donors. J Ayub Med Coll Abbottabad. 2002;14(2):24-7.

  21. Mozaheb Z, Khayami M, Sayadpoor D. Iron balance in regular blood donors. Transfus Med Hemother. 2011;38(3):190-4.

  22. Norashikin J, Roshan TM, Rosline H, Zaidah AW, Suhair AA, Rapiaah M. A study of serum ferritin levels among male blood donors in Hospital Universiti sains Malaysia. Southeast Asian J Trop Med Public Health. 2006;37(2):370-3.

  23. Yousefinejad V, Darvishi N, Arabzadeh M, Soori M, Magsudlu M, Shafiayan M. The evaluation of iron deficiency and anemia in male blood donors with other related factors. Asian J Transfus Sci. 2010;4(2):123-7.

  24. Szymczyk-Nuzka M, Wolowiec D. Prevention of sideropenic anemia in regular blood donors. Acta Haematol Pol. 2002;33(4):489-96.

  25. ____________. Iron stores in regular blood donors. Pol Arch Med Wewn. 2003;110(6):1415-21.

  26. Mahida VI, Bhatti A, Gupte SC. Iron status of regular voluntary blood donors. Asian J Transfus Sci. 2008;2(1):9-12.

  27. Mast AE, Foster TM, Pinder HL, Beczkiewicz CA, Bellissimo DB, Murphy AT, et al. Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors. Transfusion. 2008;48(10):2197-204.

  28. Radtke H, Tegtmeier J, Rocker L, Salama A, Kiesewetter H. Daily doses of 20 mg of elemental iron compensate for iron loss in regular blood donors: A randomized, double-blind, placebo-controlled study. Transfusion. 2004;44(10):1427-32.

  29. Cançado RD, Fonseca LG, Claro MRC, Tajara FS, Langhi Júnior D, Chiattone CS. Avaliação laboratorial da deficiência de ferro em doadoras de sangue. Rev Bras Hematol Hemoter. 2007;29(2):153-9.

  30. Boulahriss M, Benchemsi N. Iron deficiency in frequent and first time female blood donors. East Afr J Public Health. 2008;5(3):157-9.

  31. Mirrezaie SM, Parsi R, Torabgahromi SA, Askarian M. Low dose, short-term iron supplementation in female blood donors of childbearing age: A randomized, doublemasked, placebo-controlled study. Iran J Med Sci. 2008;33(3):138-43.

  32. Pasricha SR, McQuilten ZK, Keller AJ, Wood EM. Hemoglobin and iron indices in nonanemic premenopausal blood donors predict future deferral from whole blood donation. Transfusion. 2011;51(12):2709-13.

  33. Radtke H, Meyer T, Kalus U, Rocker L, Salama A, Kiesewetter H, et al. Rapid identification of iron deficiency in blood donors with red cell indexes provided by Advia 120. Transfusion. 2005;45(1):5-10.

  34. Birgegard G, Schneider K, Ulfberg J. High incidence of iron depletion and restless leg syndrome (RLS) in regular blood donors: intravenous iron sucrose substitution more effective than oral iron. Vox Sang. 2010;99(4):354-61.

  35. Engmann C, Adanu R, Lu TS, Bose C, Lozoff B. Anemia and iron deficiency in pregnant Ghanaian women from urban areas. Int J Gynaecol Obstet. 2008;101(1):62-6.

  36. Cogswell ME, Looker AC, Pfeiffer CM, Cook JD, Lacher DA, Beard JL, et al. Assessment of iron deficiency in US preschool children and nonpregnant females of childbearing age: National Health and Nutrition Examination Survey 20032006. Am J Clin Nutr. 2009;89(5):1334-42.

  37. Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010;1800(8):760-9.

  38. Kiudeliene R, Griniute R, Labanauskas L. Prognostic value of reticulocyte hemoglobin content to diagnose iron deficiency in 6-24-month-old children. Medicina (Kaunas). 2008;44(9):673-7.

  39. Bovy C, Gothot A, Delanaye P, Warling X, Krzesinski JM, Beguin Y. Mature erythrocyte parameters as new markers of functional iron deficiency in haemodialysis: sensitivity and specificity. Nephrol Dial Transplant. 2007;22(4):1156-62.

  40. González L, de Jesús A. Evolución del método de transfusión sanguínea y alternativas terapéuticas. Medisan. 2010;14(7):982-93.




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