Galindo-Campos M, Carrillo-Ocampo L, Cortázar-Benítez F, Aisa-Álvarez A, Rodríguez-Weber F, Díaz-Greene E

Language: Spanish
References: 17
Page: 399-403
PDF size: 183.59 Kb.

ABSTRACT

Type 2 diabetes mellitus is one of the public health problems with more relevance in the world because of its prevalence and its complications. There are many drugs that diminish glucose blood levels (principal aim in the treatment of diabetes mellitus), being the newest group the inhibitor of sodium-glucose transporter type 2 (SGLT2). The kidneys normally filter 180 g of glucose per day, this being reabsorbed by a family of transmembrane proteins called sodiumglucose transporters located in the proximal tubule. In 1970 it was discovered that the property of glucosuria of phlorizin is due to its inhibitory effect on SGLT 1 and 2. Currently dapagliflozin and other novel drugs are developed for selective inhibition of SGLT2 and apparently offer a therapeutic option for these patients. Current clinical evidence reveals the potential use of dapagliflozin as an auxiliary therapy in diabetes mellitus, as it has been shown to decrease levels of glycated hemoglobin with few adverse effects evidenced so far. Inhibitors sodium-glucose transporter is a drug adjuvant in the treatment of type 2 diabetes mellitus.

REFERENCES

1. Gutiérrez JP, Rivera-Dommarco J, Shamah-Levy T, Villalpando- Hernández S y col. Encuesta Nacional de Salud y Nutrición 2012. Resultados Nacionales. Cuernavaca: Instituto Nacional de Salud Pública (MX), 2012.

2. Instituto Nacional de Estadística, Geografía e Informática (INEGI) [Base de datos en Internet]. México: 2012 [Acceso 28 de enero 2012]. [1 pagina]. Disponible en: http://www.inegi.org.mx/sistemas/sisept/Default.aspx?t=mdemo107&s=est&c=23587.

3. American Diabetes Association. Standards of Medical Care in Diabetes-2012. Diabetes Care 2012;35:S11-S63.

4. Zhang L, Feng Y, List J, Kasichayanula S, Pfister M. Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metab 2010;12:510-516.

5. Pérez-López G, González-Albarrán O, Cano-Megías M. Inhibidores del cotransportador sodio-glucosa tipo 2 (SGLT2): de la glucosuria renal familiar al tratamiento de la diabetes mellitus tipo 2. Nefrologia 2010;30:618-625.

6. Wilding JPH, Norwood P, Tjoen C, Bastien A, et al. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers. Diabetes Care 2009;32:1656-1662.

7. Bailey C, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 2010;375:2223-2233.

8. Rosenstock J, Vico M, Wei L, Salsali A, List JF. Effects of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, on hemoglobin A1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care 2012;35:1473-1478.

9. Nauck MA, Del Prato S, Meier JJ, Durán-García S, et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequategGlycemic control with metformin. A randomized, 52-week, doubleblind, active-controlled noninferiority trial. Diabetes Care 2011;34:2015-2022.

10. Neumiller J, White J, Campbell K. Sodium-glucose cotransport inhibitors. Progress and therapeutic potential in type 2 diabetes mellitus. Drugs 2010;70:377-385.

11. Nair S, Wilding P. Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus. J Clin Endocrinol Metab 2010;95:34-42.

12. Clar C, Gill JA, Court R, Waugh N. Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. BMJ Open 2012;2:e001007. doi:10.1136/ bmjopen-2012-001007.

13. Komoroski B, Vachharajani N, Feng Y, Li L, et al. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther 2009;85:513-519.

14. Komoroski B, Vachharajani N, Feng Y, Li L, et al. Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Ther 2009;85:520-526.

15. Vallon V, Sharma K. Sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Curr Opin Nephrol Hypertens 2010;19:425-431.

16. List J, Woo V, Morales E, Tang W, Fiedorek FT. Sodiumglucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care 2009;32:650-657.

17. Kasichayanula S, Chang M, Hasegawa M, Liu X, et al. Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, in japanese subjects without and with type 2 diabetes mellitus. Diabetes Obes Metab 2011;13:357-365.