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2013, Number 103

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Rev Enfer Infec Pediatr 2013; 26.27 (103)

Diagnosis of human metapneumovirus. Systematic review of the literature

Romero FR, Romero FR, Mora MI, Romero CR, González SN

Language: Spanish
References: 137
Page: 256-269
PDF size: 328.93 Kb.


ABSTRACT

Background: Respiratory viruses are common cause of disease. Specific etiology remains without identification at least at 50% of the cases. Human Metapneumovirus is an important agent in respiratory diseases in children. There are 4 diagnostic tools for human metapneumovirus: serologic, culture, PCR and antigens.
Objective: Identify diagnostic accuracy of PCR, culture, immunofluorescence and serologic tests for human metapneumovirus in pediatric patients.
Methods: Types of studies: Diagnostic accuracy papers. Search strategy: Keywords: Human Metapneumovirus, PCR, culture, immunofluorescence, serologic studies, antibodies, diagnostic test, diagnostic, diagnostic accuracy.
Results: 169 papers, 147 were dismissed because they were not diagnostic accuracy test or because they had incomplete data. We had culture against culture (one paper), immunofluorescence against culture (one paper), PCR against culture (four papers), immunofluorescence against PCR (fourteen papers) and PCR against PCR (2 papers).
Conclusion: The diagnostic test with the best diagnostic accuracy was culture. PCR is a useful diagnostic test but more studies are needed in order to get best evidence.


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