Blancas VÁS, Escobar BC

Language: Spanish
References: 25
Page: 272-279
PDF size: 165.44 Kb.

ABSTRACT

Ingestion of sweet and tasty food is a relevant factor inducing binge eating and overconsumption of food motivated by pleasure rather than hunger. When sweet food is offered daily in a scheduled manner, rodents develop anticipatory behavior and at the brain level increased neuronal activation in corticolimbic areas at the moment of the snack delivery. This pattern of activation persists for several days after interrupting delivery of the daily scheduled snack, suggesting a timekeeping process related with dependence or addiction. The present study explored the process of development of this neuronal activation in rats receiving chocolate 5 g daily for eight days. Neuronal activation was measured with c-Fos in prelimbic cortex, nucleus accumbens, and piriform cortex on days 1, 3, 5, and 8 after ingestion of chocolate and during the interval of anticipating the daily snack. Here we report that chocolate ingestion produces the same intense activation on all days evaluated, independent of days of exposition. During expectancy and anticipation, neuronal activation builds up along the days, reaching on day 8 the same intensity as observed after ingestion. We conclude that behavioral anticipation and neuronal activation in corticolimbic areas to a palatable snack is a progressive process.

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