2013, Number 2
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Rev Mex Patol Clin Med Lab 2013; 60 (2)
Infectious etiology of asthma exacerbation
Millán RG
Language: Spanish
References: 15
Page: 91-95
PDF size: 47.42 Kb.
ABSTRACT
Asthma is a public health problem; in Mexico asthma is included among the ten causes of hospital and medical care. Exacerbations of asthma (asthma attacks or acute asthma) are episodes of progressive increase in shortness of breath, coughing, wheezing, tightness in the chest, or a combination of these symptoms. It has been identified airway infections, as the major etiology of exacerbations. Microbiological study of the sputum of the 90 patients included in this study was performed. The results showed that pathogenic microorganisms associated to asthma exacerbations were isolated in almost 50% of the samples analyzed, the pathogens isolated were bacterias followed by virus. In contrast to previous studies, in this study bacterias were isolated in higher proportion than virus. However, we are not able to conclude that bacterias or virus infections are responsible of the exacerbations, because it was not possible to found a strong association between the severity of the crisis and the presence of some pathogens.
REFERENCES
Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, Fitzgerald JM et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31: 143-178.
Masoli M, Fabian D, Holt S, Beasley R. The Global Burden of Asthma; Report. In: Global Initiative for Asthma (GINA). Allergy 2004; 59: 469-478.
Waltraud E, Markus JE, von Mutius E. The asthma Epidemic. N Engl J Med 2006; 355: 2234-2256.
Rodrigo GJ, Rodrigo C, Hall J. Acute asthma in adults. A review. Chest 2004; 125: 1081-1102.
Global Strategy for Asthma Management and Prevention. NIH Publication 02-3659, 2002.
Sociedad de Neumología y Cirugía de Tórax A.C. Consenso Mexicano de Asma. Neumol Cir Torax 2005; 7-44.
Sears MR. Epidemiology of asthma exacerbations. J Allergy Clin Immunol 2008; 122: 662-668.
Weiss KB, Sullivan SD, Lyttle CS. Trends in the cost of illness for asthma in the United States, 1985-1994. J Allergy Clin Inmunol 2000; 106: 493-499.
Expert Panel Report 3 (EPR-3). Guidelines for the diagnosis and management of asthma: summary report 2007. J Allergy Clin Immunol 2007; 120: S94-S138.
Custovic A, Murray C, Simpson A. Allergy and infection: understanding their relationship. Allergy 2005; 60 (suppl 79): 10-13.
Mallia P, Contoli M, Caramori G, Pandit A, Johnston SL et al. Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease (COPD): Focus on Virus Induced Exacerbations. Current Pharmaceutical Design 2007; 13: 73-97.
Teichtahl H, Buckmaster N, Pertnikovs E. The Incidence of Respiratory Tract Infection In Adults Requiring Hospitalization for Asthma. Chest 1997; 112: 591-596.
Biscione GL, Corne J, Chauhan AJ, Johnston SL. Increased frequency of detection of Chlamydophila pneumoniae in asthma. Eur Respir J 2004; 24: 745-749.
Sykes A, Johnston SL. Etiology of asthma exacerbations. J Allergy Clin Inmunol 2008; 122 (4).
Talbot TR, Hartert TV, Mitchel E, Halasa NB, Arbogast PG, Poehling KA et al. Asthma as a risk factor for invasive pneumococcal disease. N Engl J Med 2005; 352: 2082-2090.