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2011, Number 4

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Rev Hosp Jua Mex 2011; 78 (4)

Genética y obesidad

Chávez OS, Sierra MM

Language: Spanish
References: 19
Page: 230-239
PDF size: 218.86 Kb.


ABSTRACT

Obesity is a global health problem that is gradually affecting each continent of the world. Obesity is a heterogeneous disorder, and the biological causes of obesity are complex. The rapid increase in obesity prevalence during the past few decades is due to major societal changes (sedentary lifestyle, over-nutrition) but who becomes obese at the individual level is determined to a great extent by genetic susceptibility. In this review, we evidence that obesity is a strongly heritable disorder, and provide an update on the molecular basis of obesity. To date, nine loci have been involved in Mendelian forms of obesity and 58 loci contribute to polygenic obesity, and rare and common structural variants have been reliably associated with obesity. Most of the obesity genes remain to be discovered, but promising technologies and the use of deep phenotyping lead to optimism to prevent obesity in the near future. In the longer term, the genetic dissection of obesity will help to characterize disease mechanisms, provide new targets for drug design, and lead to an early diagnosis, treatment, and prevention of obesity.


REFERENCES

  1. Estrategia y plan de acción regionales sobre la nutrición en la salud y el desarrollo, 2006-2015. Organización Panamericana de la Salud, Organización Mundial de la Salud. Washington, D.C.:47o. Consejo Directivo. 58a. Sesión del Comité Regional. CD47/18; 2006.

  2. McMille C, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity and programming. Physiol Rev 2005; 85: 571-633.

  3. Preventing childhood obesity. Health in the balance. Committee on prevention of obesity in children and youth. Food and Nutrition Board. Board on Health Promotion and Disease Pevention. Institute of Medicine of the National Academies. Washington, D.C.: The National Academies Press; 2005. ISBN 0-309-09315-5.

  4. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. L7

  5. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA 1986; 256(1): 51-4, ancet 2011; 377(9765): 557-67

  6. Mustelin L, Silventoinen K, Pietilainen K, Rissanen A, Kaprio J. Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins. Int J Obes 2009; 33(1): 29-36.

  7. Malis C, Rasmussen EL, Poulsen P, Petersen I, Christensen K, Beck-Nielsen H, Astrup A, Vaag AA. Total and regional fat distribution is strongly influenced by genetic factors in young and elderly twins. Obes Res 2005; 13(12): 2139-45.

  8. Jarick I, Vogel CI, Scherag S, Schafer H, Hebebrand J, Hinney A, Scherag A. Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis. Hum Mol Genet 2011; 20(4): 840-85.

  9. Choquet H, Meyre D. Molecular basis of obesity: current status and future prospects. Curr Genomics 2011; 1232(3): 154-68.

  10. Fenech M. Genome health nutrigenomics: nutrition and the science of optimal genome maintenance. Asia Pac J Clin Nutr 2004; 13(Suppl.): S15.

  11. Stover P. Influence of human genetic variation on nutritional requirements. Am J Clin Nutr 2006; 83(Suppl.): S436-S442.

  12. Palou A, Bonet ML, Picó C. Nutrigenómica y obesidad. Rev Med Univ Navarra 2004; 48(2): 36-48.

  13. Hegele RA, Cao H, Harris SB. Peroxisome proliferatoractivated receptor gamma2 P12A and type 2 diabetes in Canadian Oji-Cree. J Clin Endocrinol Metab 2000; 85: 2014-9.

  14. Pisabarro RE, Sanguinetti C, Stoll M, Prendez D. High incidence of type 2 diabetes in peroxisome-proliferator-activated receptor gamma 2 Pro12Alacarriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids. Diabetes Care 2004; 27(9): 2251-2.

  15. Hernándes T, Ruiz-Álvarez V. Obesidad, una epidemia mundial. Implicaciones de la genética. Rev Cub Invest Biomed 2007; 26(3).

  16. Calkins K, Devaskar SU. Fetal origins of adult disease. Curr Probl Pediatr Adolesc Health Care 2011; 41(6): 158-76.

  17. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon J. Human nutrition, the gut microbiome and the immune system. Nature 2011; 474(7351): 327-36.

  18. Huang W, Moynihan-Ramsey K, Marcheva B, Bass J. Circadian rhythms, sleep, and metabolism. J Cli Invest 2011; 121(6): 2133-41.

  19. Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 2011; 121(6): 2126-32. Doi: 10.1172/ JCI58109 [Epub 2011].




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