2012, Number 2
<< Back Next >>
Med Sur 2012; 19 (2)
Recurrent hypertensive disease in pregnancy and associated morbidity
Romero-Ramírez MJ, Pichardo-Cuevas M, Déciga-Rivera CI, Contreras-Carreto NA
Language: Spanish
References: 20
Page: 56-59
PDF size: 63.86 Kb.
ABSTRACT
Introduction. Exist major risk factors for developing recurrent hypertensive
disorders of pregnancy (HDP) and includes the history of
antiphospholipid syndrome, nulliparity, previous history of preeclampsia,
pregestational diabetes, family history of preeclampsia,
maternal age and high greater than 10 years of evolution. This risk
is 7 times higher in pregnant women with a history of preeclampsia,
9-10 times higher in patients with antiphospholipid syndrome and 4
times greater with pre-existing diabetes.
Objective. Investigate
the prevalence of recurrent HDP and its morbidity associated.
Material and methods. Retrospective, observational, descriptive
study realized in 105 women with recurrent HDP treated at Woman’s
Hospital, Ministry of Health since 1st January 2007 to March 30th
2011.
Results. The observed prevalence of recurrent HDP was
80.95%, the study included 105 patients with an mean age of 24.2
years. The median was 2 pregnancies, 0.5 deliveries, 1 abortion,
1.5 cesareans. The average weeks of presentation of HDP was 32.8,
the average period between births was 41.8 months. Recurrent EHE
for each classification was: gestational hypertension 7.61% (n = 8),
severe preeclampsia 62.85% (n = 66), mild preeclampsia 6.66%
(n = 7), hypertension + preeclampsia 3.8% (n = 4). The prevalence
for each classification of associated morbidity was: obstetric hemorrhage
5.71% (n = 6), HELLP syndrome 11.2% (n = 12), preterm
delivery 24.76% (n = 26), intrauterine growth retardation 4.76%
(n = 5), abruptio placentae 2.85% (n = 3), and stillbirth 2.85% (n = 3).
Conclusion. While HDP is a serious clinical entity, prevalence
remains high in our population.
REFERENCES
National High Blood Pressure Education Program Working Group. Report on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 1990; 163: 1691-712.
Sibai BM. Pre-eclampsia eclampsia. Curr Problems Obstet Gynecol Fertil 1990; 13: 3-45.
Davies AM, Dunlop W. Hypertension in pregnancy. In: Barron SL, Thomson AM (eds.). Obstetrical epidemiology. London: Academic Press; 1983, p. 167-208.
Saftlas AF, Olson DR, Franks AL, Franks HK, Pokras R. Epidemiology of preeclampsia and eclampsia in the United States, 1979-1986. Am J Obstet Gynecol 1990; 163: 460-5.
Visser W, Wallenburg HC. Maternal and perinatal outcome of temporizing management in 254 consecutive patients with severe preeclampsia remote from term. Eur J Obstet Gynecol Reprod Biol 1995; 63: 147-54. Rev Invest Med Sur Mex, 2012; 19 (2): 56-59 59
Zeeman GG, Dekker GA. Pathogenesis of preeclampsia: a hypothesis. Clin Obstet Gynecol 1992; 35: 317-37.
Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: Current concepts. Am J Obstet Gynecol 1998; 179: 1359-75.
Gibson B, Hunter D, Neame PB, Kelton JG. Thrombocytopenia in preeclampsia and eclampsia. Semin Thromb Hemost 1982; 8:234-47.
Giles C, Inglis TC. Thrombocytopenia and macrothrombocytosis in gestational hypertension. Br J Obstet Gynaecol 1981; 88: 1115-9.
Pritchard JA, Cunningham FG, Mason RA. Coagulation changes in eclampsia: their frequency and pathogenesis. Am J Obstet Gynecol 1976; 124: 855-64.
Friedman SA, Taylor RN, Roberts JM. Pathophysiology of preeclampsia. Clin Perinatol 1991; 18: 661-82.
Stone JL, Lockwood CJ, Berkowitz GS, Alvarez M, Lapinski R, Berkowitz RL. Risk factors for severe preeclampsia. Obstet Gynecol 1994; 83: 357-61.
Odegard RA, Vatten LJ, Nilsen ST, Salvesen KA, Austgulen R. Risk factors and clinical manifestations of pre-eclampsia. Br J Obstet Gynaecol 2000; 107: 1410-6. Órgano de Difusión de la Sociedad de Médicos Revista de Investigación
Campbell DM, MacGillivray I, Carr-Hill R. Pre-eclampsia in second pregnancy. Br J Obstet Gynaecol 1985; 131-40.
Sibai BM, El Nazer A, Gonzalez-Ruiz A. Severe preeclampsiaeclampsia in young primigravid women: subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol 1986; 155: 1011-6.
Dukler D, Porath A, Bashiri A, Erez O, Mazor M. Remote prognosis of primiparous women with preeclampsia. Eur J Obstet Gynecol Reprod Biol 2001; 96: 69-74.
Santema JG, Koppelaar I, Wallenburg HC. Hypertensive disorders in twin pregnancy. Eur J Obstet Gynecol Reprod Biol 1995; 58: 9-13.
Garner PR, D’ Alton ME, Dudley DK, Huard P, Hardie M. Preeclampsia in diabetic pregnancies. Am J Obstet Gynecol 1990; 163: 505-8.
Pattison NS, Chamley LW, McKay EJ, Liggins GC, Butler WS. Antiphospholipid antibodies in pregnancy: prevalence and clinical
associations. Br J Obstet Gynaecol 1993; 100: 909-13. 20. Leis M, Rodríguez B, García L. Diagnóstico y tratamiento de la preeclampsia-eclampsia. Ginecol Obstet Mex 2010; 78: 461-525.