2013, Number 3
<< Back Next >>
Rev Med Inst Mex Seguro Soc 2013; 51 (3)
Obesity, the main risk factor for endometrial cancer
Ortiz-Mendoza CM, Velasco-Navarro C
Language: Spanish
References: 19
Page: 260-263
PDF size: 93.48 Kb.
ABSTRACT
Background: obesity is a well-known risk factor for endometrial cancer,
and both diseases are rising in Mexico. However, in our country some
data indicates low influence of obesity on this neoplasm, and this is contradictory.
Therefore, we explore the prevalence of obesity on women
affected with this malignant tumor.
Methods: this was a pilot case-control study in a general hospital at Mexico
City. The analysis involved obesity (a body mass index ≥ 30 kg/m
2)
diabetes mellitus and systemic arterial hypertension.
Results: the sample was of 66 women: 22 cases and 44 controls. In
cases, obesity occurred in 77 % (odds ratio [OR] 8.1, 95 % confi dence
interval [CI] 2.46-26.6); diabetes mellitus in 41 % (OR 4.3, CI 1.31-14.7);
and systemic arterial hypertension in 41 % (OR 2.3, CI 0.78-7.1).
Conclusions: these preliminary results suggested that obesity was the
most frequent risk factor for these women with endometrial cancer.
REFERENCES
Barquera S, Campos-Nonato I, Hernández-Barrera L, Flores M, Durazo-Arvizu R, Kanter R, et al. Obesity and central adiposity in Mexican adults: results from the Mexican National Health and Nutrition Survey 2006. Salud Publica Mex. 2009;51(Suppl 4): S595-S603. Disponible en http://www.scielosp. org/scielo.php?script=sci_arttext&pid=S0036-3634 2009001000014&lng=en&nrm= iso&tlng=en
Kuri-Morales P, Emberson J, Alegre-Díaz J, Tapia- Conyer R, Collins R, Peto R, et al. The prevalence of chronic diseases and major disease risk factors at different ages among 150,000 men and women living in Mexico City: cross-sectional analyses of a prospective study. BMC Public Health. 2009;9:9. Disponible en http://www.ncbi.nlm.nih.gov/pmc/articles/ PMC2645387/
Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D, et al. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ. 2007;335:1134.
Rojas R, Aguilar-Salinas CA, Jiménez-Corona A, Shama-Levy T, Rauda J, Ávila-Burgos L, et al. Metabolic syndrome in Mexican adults. Results from the National Health and Nutrition Survey 2006. Salud Pública Méx. 2010;52 (Suppl 1):S11-S18. Disponible en http://www. scielosp.org/scielo.php?script=sci_arttext&pid=S0036 -36342010000700004&lng=en&nrm=iso&tlng=en
Conroy MB, Sattelmair JR, Cook NR, Manson JE, Buring JE, Lee IM. Physical activity, adiposity, and risk of endometrial cancer. Cancer Causes Control. 2009;20(7):1107-15.
Instituto Nacional de Estadística y Geografía (INEGI) [Internet]. Mortalidad por tumores; 2011. [Consultado el 2 de febrero del 2012]. Disponible en http://www.inegi.org.mx/est/contenidos/Proyectos/ registros/vitales/mortalidad/default.aspx
Salazar-Martínez E, Lazcano-Ponce EC, Lira-Lira GG, Escudero-De los Ríos P, Salmerón-Castro J, Larrea F, et al. Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cancer Causes Control. 2000;11(8):707-11.
Soliman PT, Oh JC, Schmeler KM, Sun CC, Slomovitz BM, Gershenson DM, et al. Risk factors for young premenopausal women with endometrial cancer. Obstet Gynecol. 2005;105(3):575-80.
Lindemann K, Vatten LJ, Ellstrom-Engh M, Eskild A. Body mass, diabetes and smoking, and endometrial cancer risk: a follow-up study. Br J Cancer. 2008; 98(9):1582-5.
González-Enciso A, Hernández-López L, Herbert- Núñez G. Cáncer de endometrio: abordaje diagnóstico y terapéutico: experiencia en el Instituto Nacional de Cancerología. Rev Inst Nac Cancerol (Méx). 1999;45(4):243-50.
Torres-Lobatón A, Hernández-Fragoso F, Hernández- Naranjo MA, Román-Basure E, Rojo-Herrera G, Oliva-Posada JC, et al. Cáncer de endometrio. Estado actual de frecuencia por estadios y resultados del tratamiento en el Hospital General de México. GAMO. 2004;3(4):21-5.
Key TJ, Pike MC. The dose-effect relationship between “unopposed” oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk. Br J Cancer. 1988;57(2):205- 12. Disponible en http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2246441/
Kaaks R, Lukanova A, Kurzer M. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev. 2002;11(12):1531-43.
Friberg E, Mantzoros CS, Wolk A. Diabetes and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2007;16(2):276-80.
Lucenteforte E, Bosetti C, Talamini R, et al. Diabetes and endometrial cancer: effect modifi cation by body weight, physical activity and hypertension. Br J Cancer. 2007;97(7):995-8. Disponible en http://www.nature. com/bjc/journal/v97/n7/full/6603933a.html
Saltzman BS, Doherty JA, Hill DA, Beresford SA, Voigt LF, Chen C, et al. Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors. Am J Epidemiol. 2008;167(5):607- 14. Disponible en http://aje.oxfordjournals.org/content/ 167/5/607.long
Giovannucci E. Nutrition, insulin, insulin-like growth factors, and cancer. Horm Metab Res. 2003;35(11-12): 694-704.
Berstein LM, Kvatchevskaya JO, Poroshina TE, Kovalenko IG, Tsyrlina EV, Zimarina TS, et al. Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer. J Cancer Res Clin Oncol. 2004; 130(11):687-93.
Nestler JE, Powers LP, Matt DW, Steingold KA, Plymate SR, Rittmaster RS, et al. A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J Clin Endocrinol Metab. 1991;72 (1):83-9.