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ISSN 2448-8909 (Print)

2001, Number 3

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Med Crit 2001; 15 (3)

Comparison between cisatracurium and vecuronium on the neuromuscular blockade in critically ill patients assisted with mechanical ventilation

Revilla REA, Molinar RF, Vázquez HMI, Baltazar TJA , Cruz ME

Language: Spanish
References: 20
Page: 87-91
PDF size: 56.10 Kb.


ABSTRACT

Objective: To establish a comparison between cisatra-curium and vecuronium on the neuromuscular blockade in patients assisted with mechanical ventilation. Design: Case series report. Setting: ICU of a tertiary care hospital, Mexico City. Patients: Twenty critically ill patients. Interventions: Ten patients (group A) received cisatra-curium (initial doses), 0.15 mg/kg, followed by 2-3 mg/kg/min during 24 hours. Ten patients (group B) were treated with an initial doses of vecuronium (0.1 mg) followed by a IV continuous infusion of 0.05 a 0.1 mg/kg/min during 24 hours. Measurements and main results: The neuromuscular blockade monitoring was made trough using the train-of-four method (TOF). TOF, initiation time, counts number and recovery time were registered. In group A the initiation time was 2.8 ± 2.04 min, recovery time 31.15 ± 34.79 min, average TOF 12.2 ± 11.61, and the counts number 2.1 ± 0.99. In group B the initiation time was 2.0 ± 1.56 min, recovery time was 30.1 ± 67.2 min, the average TOF 2.6 and 4.48 min and counts number 1.3 ± 0.82. Non significant difference was observed between the both groups. Conclusion: In this study the effects on the neuromuscular blockade by cisatracurim and vecuronium in critically ill ventilated patients were similar.


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