Morales RE, Marcheco TB, Robaina JZ, Soriano TM, Méndez RLA, del Sol GM

Language: Spanish
References: 21
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ABSTRACT

Introduction: schizophrenia is a mental disorder affecting world population, with a prevalence of 1% and inheritability to 80%. Cytogentics and molecular investigations have identified a great number of chromosomal aberrations in patients with schizophrenia that equally involve as many autosomic as sexual chromosomes.
Objetive: to identify aberrations and polymorphisms with possibly associated to schizophrenia in individuals within Cuban population, to obtain the frequency of chromosomal aberrations in individuals with schizophrenia, and to identify the most involved chromosomes in the studied individuals.
Methods: a cross and descriptive case study was carried out. The study universe was conformed by patients with schizophrenia. Lymphocytes cultivation technique in high resolution was used. Results: structural and numerical aberrations, mosaics and polymorphisms were identified.
Conclusions: the pericentric inversion, the increase of the 9-chromosome heterochromatic region, and the X chromosome aneuploidy, were the more frequent chromosomal alterations observed in the course of research. Due to their high frequency in this population of affected individuals, we believe that chromosomal alterations implication should be investigated as a possible susceptibility locus to schizophrenia, which could be located in one of the breaking points of the aforementioned chromosomes.

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