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2001, Number 2

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Arch Cardiol Mex 2001; 71 (2)

Changes in oxigenation index induced by NO inhalation during the postoperative period of congenital heart repair with severe pulmonary hypertension in children

Ramírez RL, Calderón CJ, Zarco ME, García MJA, Molina MM, Fernández RG

Language: Spanish
References: 23
Page: 121-126
PDF size: 58.51 Kb.


ABSTRACT

In this clinical study, 7 pediatric patients with severe pulmonary artery hypertension, secondary to congenital heart disease, received inhaled nitric oxide at doses of 20 ppm in the acute postoperative management of congenital heart repair for 3.5 days. Monitoring included oxigenation index, alveoloarterial oxygen difference, pulmonary and systemic pressure, measurements were recorded previous to the NO administration; 1, 6, 12, 24, 36, 48 and 72 hours after treatment with NO, nitrous oxide (NO2) and seric methemoglobin also were monitored. Results. Average age was 3.6 years. The oxigenation index before inhaling NO was 166 ± 100, 72 hours following inhalation of NO the oxigenation index was 210 ± 98. The alveolo-arterial baseline oxygen difference was 270 ± 145; 72 hours after inhaling NO, it was 163 ± 167. No decreases in pulmonary and systemic arterial pressure during NO inhalation ocurred. The levels of NO2 and seric methemoglobin were not toxic. Conclusions: Treatment with inhaled NO after cardiac surgery in children with severy pulmonary artery hypertension secondary to congenital heart disease may be useful to improve oxigenation with no changes in pulmonary and systemic arterial pressure. Inhaled NO at 20 ppm did not cause toxicity.


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