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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2008, Number 5

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Rev Invest Clin 2008; 60 (5)

Survival after radical prostatectomy in patients with prostate cancer and seminal vesicle invasion

Castillejos-Molina RA, Rodríguez-Covarrubias F, Sotomayor ZM, Uribe-Uribe N, Lino LS, Feria-Bernal G

Language: Spanish
References: 28
Page: 360-364
PDF size: 57.20 Kb.


ABSTRACT

Objective. To assess the outcome of patients with clinically localized prostate cancer (PCa) and seminal vesicle invasion (SVI) in the radical prostatectomy (RP) specimen. Material and methods. 212 patients with clinically localized PCa underwent RP at our institution from 1988 to 2007. SVI (stage pT3bN0M0 of the TNM 2002 system) was demonstrated in 40 (18.9%). Results. Patients with SVI and PSA ‹ 10 ng/mL had better prognosis than those with a PSA ≥ 10 ng/mL, with a 5-year biochemical progression-free survival (bPFS) of 68.2% and 19.9%, respectively (p = 0.008). In univariate analysis, an initial prostate specific antigen (PSA) ≥ 10 ng/mL (p = 0.01) and preoperative high risk group (p = 0.05) were related to the likelihood of biochemical failure. In multivariate analysis, only PSA remained independently associated to the risk of biochemical recurrence. Conclusions. In the present study, the frequency of SVI was 18.9%. SVI confers a poor prognosis. Preoperative PSA ≥ 10 ng/mL was associated to the risk of biochemical recurrence.


REFERENCES

  1. Montie JE. Current prognostic factors for prostate carcinoma. Cancer 1996; 78: 341-4.

  2. Mukamel E, de Kernion JB, Hannah J, et al. The incidence and significance of seminal vesicle invasion in patients with adenocarcinoma of the prostate. Cancer 1987; 59: 1535-9.

  3. Rodríguez-Covarrubias F, Castillejos-Molina R, Sotomayor de Zavaleta M, et al. Recurrencia bioquímica según el grupo de riesgo en pacientes con adenocarcinoma de próstata. Rev Mex Urol 2004; 64(1): 6-12.

  4. Solares SME, Soel EJ, Viveros EJM, et al. Análisis de sobrevida en pacientes sometidos a prostatectomía radical, en población mexicana. Seguimiento a cinco años. Rev Mex Urol 2004; 64(2): 54-66.

  5. D’Amico AV, Whittington R, Malkowicz SB, et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy or interstitial radiation therapy for clinically localized prostate cancer. JAMA 1998; 280: 969-74.

  6. Villers AA, McNeal JE, Redwine EA, et al. Pathogenesis and biological significance of seminal vesicle invasion in prostatic adenocarcinoma. J Urol 1990; 143: 1183-7.

  7. Villers A, McNeal JE, Redwine EA, et al. The role of perineural space invasion in the local spread of prostatic adenocarcinoma. J Urol 1989; 142: 763-8.

  8. Salomon L, Anastasiadis AG, Johnson CW, et al. Seminal Vesicle Involvement After Radical Prostatectomy: Predicting Risk Factors For Progression. Urology 2003; 62: 304-9.

  9. Billis A, Teixeira DA, Stelini RF, et al. Seminal vesicle invasion in radical prostatectomies: which is the most common route of invasion?. In Urol Nephrol 2007; 39(4): 1097-102.

  10. Wheeler TM. Anatomic considerations in carcinoma of the prostate. Urol Clin North Am 1989; 16: 623-34.

  11. Ohori M, Scardino PT, Lapin SL, et al. The mechanisms and prognostic significance of seminal vesicle involvement by prostate cancer. Am J Surg Pathol 1993; 17: 1252-61.

  12. Epstein JI, Carmichael M, Walsh PC. Adenocarcinoma of the prostate invading the seminal vesicle: definition and relation of tumor volume, grade and margins of resection to prognosis. J Urol 1993; 149: 1040-5.

  13. Bloom KD, Richie JP, Schultz D, et al. Invasion of seminal vesicles by adenocarcinoma of the prostate: PSA outcome determined by preoperative and postoperative factors. Urology 2004; 63: 333-6.

  14. Valicenti R, Gomella L, Ismail M, et al. Pathologic seminal vesicle invasion after radical prostatectomy for patients with prostate carcinoma: effect of early adjuvant radiation therapy on biochemical control. Cancer 1998; 82: 1909-14.

  15. Valicenti R, Gomella L, Ismail M, et al. The efficacy of early adjuvant radiation therapy for pT3N0 prostate cancer: a matched-pair analysis. Int J Radiat Oncol Biol Phys 1999; 45: 53-8.

  16. Lee HM, Solan MJ, Lupinacci P, et al. Long-term outcome of patients with prostate cancer and pathologic seminal vesicle invasion (pT3b): effect of adjuvant radiotherapy. Urology 2004; 64: 84-9.

  17. Greco C, Castiglioni S, Fodor A, et al. Benefit on biochemical control of adjuvant radiation therapy in patients with pathologically involved seminal vesicles after radical prostatectomy. Tumori 2007; 93(5): 445-51.

  18. Eggener SE, Roehl KA, Smith ND, et al. Contemporary survival results and the role of radiation therapy in patients with node negative seminal vesicle Invasion following radical prostatectomy. J Urol 2005; 173: 1150-5.

  19. Bolla M, van Poppel H, Collete L, et al. Postoperative radiotherapy after radical prostatectomy: a randomized controlled trial (EORTC trial 22911). Lancet 2005; 366(9485): 572-8.

  20. Thompson I, Tangen C, Paradelo J, et al. Adjuvant radiotherapy for pathologically advanced prostate cancer: A randomized Clinical Trial. JAMA 2006; 296: 2329-35.

  21. Swanson GP, Thompson IM. Adjuvant radiotherapy for highrisk patients following radical prostatectomy. Urol Oncol 2007; 25(6): 515-9.

  22. Swanson GP, Hussey MA, Tangen CM, et al. Predominant treatment failure in postprostatectomy patients is local: Analysis of patterns of treatment failure in SWOG 8794. J Clin Oncol 2007; 25: 2225-9.

  23. Lieberman S, Lowe B. Disease recurrence and progression in untreated pathologic stage T3 prostate cancer: selecting the patient for adjuvant therapy. J Urol 1997; 158: 1452-6.

  24. Zinke H, Lau W, Bergstralh E, et al. Role of early adjuvant hormonal therapy after radical prostatectomy for prostate cancer. J Urol 2001; 166: 2208-15.

  25. Eulau S, Tate D, Stamey T, et al. Effect of combined transient androgen deprivation and irradiation following radical prostatectomy for prostate cancer. Int J Radiat Oncol Biol Phys 1998; 41: 735-40.

  26. Baccala A Jr, Alwyn MR, Bianco FJ, et al. Complete resection of seminal vesicles at radical prostatectomy results in substantial long-term disease-free survival: multi-institutional study of 6740 patients. Urology 2007; 69: 536-40.

  27. Koh H, Kattan MW, Scardino PT, et al. A nomogram to predict seminal vesicle invasion by the extent and location of cancer in systematic biopsy results. J Urol 2003; 170: 1203-8.

  28. Gallina A, Chun FK, Briganti A, et al. Development and splitsample validation of a nomogram predicting the probability of seminal vesicle invasion at radical prostatectomy. Eur Urol 2007; 52: 98-105.




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