Castillejos-Molina RA, Rodríguez-Covarrubias F, Sotomayor ZM, Uribe-Uribe N, Lino LS, Feria-Bernal G

Idioma: Español
Referencias bibliográficas: 28
Paginas: 360-364
Archivo PDF: 57.20 Kb.

RESUMEN

Objetivo. Conocer la supervivencia de pacientes con CaP clínicamente localizado, en quienes se demostró IVS después de la PRR. Material y métodos. Se realizó un estudio retrospectivo, descriptivo de 212 pacientes tratados con PRR por CaP clínicamente localizado en nuestro instituto de 1988 a 2007. En el análisis patológico definitivo, identificamos a 40 (18.9%) pacientes con invasión a vesículas seminales (pT3bN0M0), de acuerdo al sistema TNM 2002. Resultados. Los pacientes con IVS y APE menor a 10 ng/mL mostraron mejor evolución en comparación al grupo con APE ≥ 10 ng/mL, con SLRB a 5 años de 68.2% y 19.9%, respectivamente (p = 0.008). En el análisis univariado un APE preoperatorio ≥ 10 ng/mL (p = 0.01) y el grupo con criterios de riesgo preoperatorio alto (p = 0.05) se asociaron con riesgo de recurrencia bioquímica. En el análisis multivariado, sólo el APE preoperatorio mantuvo una asociación independiente con la posibilidad de recurrencia bioquímica. Conclusiones. Identificamos una frecuencia de 18.9% de invasión a vesículas seminales. Los pacientes con IVS y APE menor a 10 ng/mL tienen mejor pronóstico que aquellos con APE ≥ 10 ng/mL. El APE preoperatorio es un factor que predice en forma independiente la posibilidad de recurrencia bioquímica.

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