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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2008, Number 4

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Rev Invest Clin 2008; 60 (4)

The peritoneal transport type might be distinctive among different Mexican populations on capd

Rojas-Campos E, Martínez-Ramírez HR, Cortés-Sanabria L, González L, Martín-del-Campo F, Monteón-Ramos F, Gómez-Navarro B, Cueto-Manzano AM

Language: Spanish
References: 29
Page: 284-291
PDF size: 102.36 Kb.


ABSTRACT

Introduction. The peritoneal equilibration test (PET), standardized by Twardowski et al. more than 20 years ago, is the most common test to classify peritoneal transport. Some reference values from Mexican population were established in the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ) 10 years ago. The aims of this study were to evaluate the peritoneal transport in a population from the west of Mexico, and compare results with those obtained in the studies of Twardowski and the INCMNSZ. Material and methods. Cross-sectional study, performed in 156 patients. All consecutive CAPD patients to whom a PET was performed between January 2000 and January 2004 were included. Each patient had a standard PET consistent on infusion of a freshly 2L dialysis exchange at 2.5% after drainage of the previous nocturnal exchange; 3 dialysis aliquots at 0, 2 and 4 hours, and a blood sample at 2 hours, are obtained after infusion. Results were compared to those reported by Twardowski and INCMNSZ. Results. From the total of patients, 48% were diabetics and 62% were men. Mean age was 46 ± 16 years and body surface area was 1.70 ± 0.23 m2. There were no differences between groups regarding diabetes and peritonitis. Time on dialysis was shorter in our study than in the INCMNSZ (14.6 ± 17.8 vs. 20.8 ± 21.4 months; p ‹ 0.05). Compared to those from Twardowski and INCMNSZ, creatinine D/P ratios at 0, 2 and 4 h of our study were higher, whereas D/D0 ratios at 2 and 4 h, and PET drained volume, were lower. Using reference values obtained in the present study, high transport (H) was present in 18%, high average (HA) in 33%, low average (LA) in 34% and low (L) in 15%, whereas employing the INCMNSZ reference values, H was present in 23%, HA in 36%, LA in 33% and L in 8%. Conclusions. Patients from this studied population had mean peritoneal transport values higher than those obtained in other studies, including Mexican values. Ideally, it is recommendable to determine reference values in all peritoneal dialysis centers, as extrapolating results from other regions may lead to errors in diagnosing the peritoneal transport type.


REFERENCES

  1. Twardowski ZJ, Nolph KD, Khanna R, Prowant BF, Ryan LP, Moore HL, et al. Peritoneal equilibration test. Perit Dial Bull 1987; 7: 138-47.

  2. Cueto-Manzano AM, Díaz-Alvarenga A, Correa-Rotter R. Analysis of the peritoneal equilibration test in Mexico and of factors influencing the peritoneal transport rate. Perit Dial Int 1999; 19: 45-50.

  3. Rumpsfeld M, McDonald SP, Purdie DM, Collins J, Johnson DW. Predictors of baseline peritoneal transport status in Australian and New Zealand peritoneal dialysis patients. Am J Kidney Dis 2004; 43: 492-501.

  4. Agrawal DK, Sharma AP, Gupta A, Sharma RK, Pander CM, et al. Peritoneal equilibration test in Indian patients on continuous ambulatory peritoneal dialysis: does it affect patient outcome? Adv Perit Dial 2000; 16: 148-51.

  5. Wong FKM, Li CS, Mak CK, Chaw KF, Choi KS. Peritoneal equilibration test in Chinese patients. Adv Perit Dial 1994; 10: 38-41.

  6. Davies SJ, Brown B, Bryan J, Russell GI. Clinical evaluation of the peritoneal equilibration test: a population-based study. Nephrol Dial Transplant 1993; 8: 64-70.

  7. Cueto-Manzano AM, Correa-Rotter R. Is High peritoneal transport rate an independent risk factor for CAPD mortality? Kidney Int 2000; 57: 314-20.

  8. Churchil DN, Thorpe KE, Nolph KD, Keshaviah PR, Oreopoulos DG, Pagé D. Increased peritoneal transport is associated with decreased patient and technique survival for continuous peritoneal dialysis patients. J Am Soc Nephrol 1998; 9: 1285-92.

  9. Rojas-Campos E, Alcántar-Medina M, Cortés-Sanabria L, Martinez- Ramírez HR, Camarena JL, et al. Patient and technique survival in continuous ambulatory peritoneal dialysis in a single center of the west of Mexico. Rev Invest Clin 2007; 59: 184-91.

  10. Garcia-Garcia G, Nuñez-Martínez MG, Obrador GT. Prevalence of malnutrition in low-income Mexican CAPD patients. Perit Dial Int 2003; 23: 501-3.

  11. Daniel WW. Estadística Descriptiva. En: Bioestadística. Base para el análisis de las ciencias de la salud. 4a. Ed. México, D.F.: Editorial Limusa; 2002, p. 15-56.

  12. Fernández P, García JE, Ávila DE. Estimaciones de la población indígena en México. Consejo Nacional de Población (CONAPO): http://www.conapo.gob.mx/publicaciones/2002/13.pdf (Accesado el 25 marzo 2007).

  13. Cueto-Manzano AM. Peritoneal dialysis in México. Kidney Int 2003; 63(Suppl. 83): S90-S92.

  14. Cueto-Manzano AM, Gamba G, Abasta-Jiménez M, Correa-Rotter R. Consistency of the peritoneal equilibration test in a cohort of nonselected Mexican CAPD patients. Adv Perit Dial 1995; 11: 114-19.

  15. Rodby RA, Firanek CA, Sarpolis AL. Re-evaluation of solute transport groups using the peritoneal equilibration test. Perit Dial Int 1999; 19: 438-41.

  16. Margetts PJ, McMullin JP, Rabbat CG, Churchill DN. Peritoneal membrane transport and hypoalbuminemia; cause or effect? Perit Dial Int 2000; 20: 14-18.

  17. Chung SH, Chu, WS, Lee A, Kim YH, Lee IS, Lindholm B, Lee HB. Peritoneal transport characteristics, comorbid diseases and survival in CAPD patients. Perit Dial Int 2000; 20: 541-7.

  18. Tzamaloukas AH, Murata GH, Malhotra D, Rao P, et al. Smallsolute clearances in diabetic subjects on continuous ambulatory peritoneal dialysis: comparison to nondiabetic subjects. Adv Perit Dial 1999; 15: 179-82.

  19. Smit W, van Esch S, Struijk DG, Krediet RT. Free water transport in patients starting with peritoneal dialysis: a comparison between diabetic and non diabetic patients. Adv Perit Dial 2004; 20: 13-17.

  20. Cueto-Manzano AM, Quintana-Piña E, Correa-Rotter R. Longterm CAPD survival and analysis of mortality risk factors: 12- year experience of a single Mexican center. Perit Dial Int 2001; 21: 148-53.

  21. Davies SJ, Bryan J, Phillips L, Russell GI. Longitudinal changes in peritoneal kinetics: the effects of peritoneal dialysis and peritonitis. Nephrol Dial Transplant 1996; 11: 498-506.

  22. Daly LE, Bourke GJ, McGilvray J. In: Interpretation and uses of medical statistics. 4th. Ed. London: Blackwell Science Ltd; 1995, p. 175-7.

  23. Rumpsfeld M, McDonald SP, Johnson DW. Higher peritoneal transport status is associated with higher mortality and technique failure in the Australian and New Zealand peritoneal dialysis patient populations. J Am Soc Nephrol 2006; 17: 271-8.

  24. Teixidó J, Borràs M, Martínez JC. Fundamentos teóricos de la diálisis peritoneal. En: Montenegro J, Olivares J (eds.). La diálisis peritoneal. Madrid: Dibe SL; 1999, p. 57-151.

  25. Gorodezky C. Genetic difference between Europeans and Indians: tissue and blood types. In: Columbus and the new world: medical implications. OceanSide Publications Inc, Providence, p. 43-8. IngentaConnect: http://www.ingentaconnect.com/content/ocean/cnw (accesado 25 marzo 2008).

  26. Cerda-Flores RM, Villalobos-Torres MC, Barrera-Saldaña HA, Cortés-Prieto LM, Barajas LO, et al. Genetic admixture in three Mexican Mestizo populations based on D1S80 and HLADQA1 loci. Am J Hum Biol 2002; 14: 257-63.

  27. Prado-León LR, Avila-Chaurand R, González-Muñoz EL. Anthropometric study of Mexican primary school children. Appl Ergon 2001; 32: 339-45.

  28. Fragoso JM, Juárez-Cedillo T, Hernández-Pacheco G, et al. Cytochrome P4501A1 polymorphisms in the Amerindian and Mestizo populations of Mexico. Cell Biochem Funct 2005; 23: 189-93.

  29. Vargas-Alarcón G, Gamboa R, Vergara Y, Rodriguez-Zepeda JM, de la Peña A, Izaguirre R, et al. LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians. Genes and Immunity 2002; 3: 373-7.




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