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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2010, Number 1

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Rev Invest Clin 2010; 62 (1)

Airway resistance and urinary LTE4 in children with bronchopulmonary dysplasia. Preliminary report

Vargas MH, Ojeda-Luna NG, Furuya MEY, Arreola-Ramírez JL, Zúñiga-Vázquez G

Language: Spanish
References: 43
Page: 15-22
PDF size: 91.35 Kb.


ABSTRACT

Objective. To assess airway resistance values and urinary leukotriene E4 (LTE4) concentrations before and after salbutamol inhalation in children with bronchopulmonary dysplasia (BPD). Material and Methods. Children with BPD were cross-sectionally studied to measure airway resistance by the interrupter technique (Rint), before and after inhaling 200 µg salbutamol, and to quantify urinary leukotriene E4 (LTE4) by immunoassay. Results. Thirty one children with BPD (15 females) aged between 3 months and 9 years were studied. Our results showed that LTE4 did not correlate with Rint values (r = 0.12, p = 0.52) even after adjusting by gender, atopy history, steroid use, and gastroesophageal reflux. Likewise, LTE4 did not correlate with the degree of the airway response to salbutamol (r = –0.13, p = 0.50). A strong inverse association between age and Rint (r = –0.58, p ‹ 0.001) was observed. Conclusion. We concluded that urinary LTE4 did not correlate with airway resistance or with the response to a bronchodilator drug in children with BPD, suggesting that leukotrienes are not involved in airway obstruction in this disease.


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