2010, Number 5
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Rev Invest Clin 2010; 62 (5)
Injuries, accidents and mortality in epilepsy: A review of its prevalence risk factors and prevention
Téllez-Zenteno JF, Nguyen R, Hernández-Ronquillo L
Language: Spanish
References: 70
Page: 466-479
PDF size: 107.07 Kb.
ABSTRACT
Currently, there is intense clinical research into various aspects of the medical risks relating to epilepsy, including total and cause-specific mortality, accidents and injuries in patients with epilepsy and mortality related with seizures. Submersion injuries, motor vehicle accidents, burns, and head injuries are among the most feared epilepsy-related injuries. Published risk factors for injuries include the number of antiepileptic drugs, history of generalized seizures, and seizure frequency. In general, studies focusing on populations with more severe forms of epilepsy tend to report substantially higher risks of injuries than those involving less selected populations. On the other hand, studies based in non selected populations of people with epilepsy have not shown an increase frequency of injuries in people with epilepsy compared with the general population. Some studies have shown that patients with epilepsy are more frequently admitted to the hospital following an injury. Possible explanations include are more cautious attitude of clinicians toward injuries occurring in the setting of seizures; hospitalization required because of seizures and not to the injuries themselves; and hospitalization driven by other issues, such as comorbidities, which are highly prevalent in patients with epilepsy. This article reviews information about specific type of injuries such as fractures, burns, concussions, dislocations, etc. Finally this article review in a comprehensive way information of mortality in patients with epilepsy. Aspects of mortality discussed in this review are: epidemiology, causes of mortality, sudden death in epilepsy and prevention measures
REFERENCES
Van den BM, Beghi E. Accidents in patients with epilepsy: types, circumstances, and complications: a European cohort study. Epilepsia 2004; 45(6): 667-72.
Aldenkamp A, Arends J. The relative influence of epileptic EEG discharges, short nonconvulsive seizures, and type of epilepsy on cognitive function. Epilepsia 2004; 45(1): 54-63.
Tellez-Zenteno JF, Hunter G, Wiebe S. Injuries in people with self-reported epilepsy: a population-based study. Epilepsia 2008; 49(6): 954-61.
Buck D, Baker GA, Jacoby A, Smith DF, Chadwick DW. Patients' experiences of injury as a result of epilepsy. Epilepsia 1997; 38(4): 439-44.
Spitz MC. Injuries and death as a consequence of seizures in people with epilepsy. Epilepsia 1998; 39(8): 904-7.
Beghi E. Injuries in patients with epilepsy. Lancet Neurol 2005; 4(2): 71-2.
Beghi E, Cornaggia C. Morbidity and accidents in patients with epilepsy: results of a European cohort study. Epilepsia 2002; 43(9):1076-83.
Lawn ND, Bamlet WR, Radhakrishnan K, O'Brien PC, So EL. Injuries due to seizures in persons with epilepsy: a populationbased study. Neurology 2004; 63(9): 1565-70.
Tellez-Zenteno J, Wiebe S. Injuries in epilepsy. A population based study. Neurology 2006; 66: 387-8.
Aboukasm AG, Smith BJ. Nocturnal vertebral compression fracture. A presenting feature of unrecognized epileptic seizures. Arch Fam Med 1997; 6(2): 185-7.
Kristiansen B, Christensen S. Fractures of the proximal end of the humerus caused by convulsive seizures. Injury 1984; 16(2): 108-09.
Persson HB, Alberts KA, Farahmand BY, Tomson T. Risk of extremity fractures in adult outpatients with epilepsy. Epilepsia 2002; 43(7): 768-72.
Vestergaard P. Epilepsy, osteoporosis and fracture risk- a metaanalysis. Acta Neurol Scand 2005; 112(5): 277-86.
Souverein PC, Webb DJ, Petri H, Weil J, Van Staa TP, Egberts T. Incidence of fractures among epilepsy patients: a population- based retrospective cohort study in the General Practice Research Database. Epilepsia 2005; 46(2): 304-10.
Nei M, Bagla R. Seizure-related injury and death. Curr Neurol Neurosci Rep 2007; 7(4): 335-41.
Sheth RD, Wesolowski CA, Jacob JC, et al. Effect of carbamazepine and valproate on bone mineral density. J Pediatr 1995; 127(2): 256-62.
Stephen LJ, McLellan AR, Harrison JH, et al. Bone density and antiepileptic drugs: a case-controlled study. Seizure 1999; 8(6): 339-42.
Annegers JF, Melton LJ, III, Sun CA, Hauser WA. Risk of agerelated fractures in patients with unprovoked seizures. Epilepsia 1989; 30(3): 348-55.
Vestergaard P, Tigaran S, Rejnmark L, Tigaran C, Dam M, Mosekilde L. Fracture risk is increased in epilepsy. Acta Neurol Scand 1999; 99(5): 269-75.
Cockerell OC, Sander JW, Shorvon SD. Remission of epilepsy. The NGPS. National General Practice Study of Epilepsy. Lancet 1995; 346(8984): 1228.
Gosens T, Poels PJ, Rondhuis JJ. Posterior dislocation fractures of the shoulder in seizure disorders-two case reports and a review of literature. Seizure 2000; 9(6): 446-8.
Shaw JL. Bilateral posterior fracture-dislocation of the shoulder and other trauma caused by convulsive seizures. J Bone Joint Surg Am 1971; 53(7): 1437-40.
Buhler M, Gerber C. Shoulder instability related to epileptic seizures. J Shoulder Elbow Surg 2002; 11(4): 339-44.
Silbergeld DL, Harkness WF, Bell BA, Bircher MD. Posterior fracture dislocation of the shoulder secondary to epileptic seizures. J R Coll Surg Edinb 1991; 36(2): 139-40.
Krauss GL, Ampaw L, Krumholz A. Individual state driving restrictions for people with epilepsy in the US. Neurology 2001; 57(10): 1780-5.
Sheth SG, Krauss G, Krumholz A, Li G. Mortality in epilepsy: driving fatalities vs other causes of death in patients with epilepsy. Neurology 2004; 63(6): 1002-7.
Beghi E, Sander JW. Epilepsy and driving. BMJ 2005; 331(7508): 60-1.
Bird JM, Dembny AT, Sandeman D, Butler S. Sudden unexplained death in epilepsy: an intracranial monitored case. Ref Type Generic 1997; 38: S52-S56.
McLachlan RS, Starreveld E, Lee MA. Impact of mandatory physician reporting on accident risk in epilepsy. Epilepsia 2007; 48(8): 1500-05.
Lings S. Increased driving accident frequency in Danish patients with epilepsy. Neurology 2001; 57(3): 435-9.
Krauss GL, Krumholz A, Carter RC, Li G, Kaplan P. Risk factors for seizure-related motor vehicle crashes in patients with epilepsy. Neurology 1999; 52(7): 1324-9.
Masland RL. The physician’s responsibility for epileptic drivers. Ann Neurol 1978; 4(6):485-6.
Waller JA. Chronic medical conditions and traffic safety: review of the California experience. N Engl J Med 1965; 273(26): 1413-20.
Bull JP, Jackson DM, Walton C. Causes and prevention of domestic burning accidents. BMJ 1964; 2(5422): 1421-7.
Josty IC, Narayanan V, Dickson WA. Burns in patients with epilepsy: changes in epidemiology and implications for burn treatment and prevention. Epilepsia 2000; 41(4): 453-6.
Maisels DO, Corps BV. Burned epileptics. Lancet 1964; 1(7346): 1298-301.
Richards EH. Aspects of epilepsy and burns. Epilepsia 1968; 9(2): 127-35.
Tempest MN. A survey of domestic burns and scalds in Wales during 1955; some observations on their prevention and the social responsibility of the medical profession. BMJ 1956; 1(4980): 1387-92.
Rimmer RB, Bay RC, Foster KN, et al. Thermal injury in patients with seizure disorders: an opportunity for prevention. J Burn Care Res 2007; 28(2): 318-23.
Spitz MC, Towbin JA, Shantz D, Adler LE. Risk factors for burns as a consequence of seizures in persons with epilepsy. Epilepsia 1994; 35(4): 764-7.
Hampton KK, Peatfield RC, Pullar T, Bodansky HJ, Walton C, Feely M. Burns because of epilepsy. BMJ 1988; 296(6637): 1659-60.
Centers for Disease Control and Prevention (CDC). Hospitalization for epilepsy-United States, 1988-1992. MMWR 1995; 44(43): 818-21.
Currie CJ, Morgan CL, Peters JR, Kerr M. The demand for hospital services for patients with epilepsy. Epilepsia 1998; 39(5): 537-44.
Zwimpfer TJ, Brown J, Sullivan I, Moulton RJ. Head injuries due to falls caused by seizures: a group at high risk for traumatic intracranial hematomas. J Neurosurg 1997; 86(3): 433-7.
ILAE. ILAE Commission report. Restrictions for children with epilepsy. Commission of Pediatrics of the ILAE. International League Against Epilepsy. Epilepsia 1997; 38(9): 1054-6.
Jones MW. Consequences of epilepsy: why do we treat seizures? Can J Neurol Sci 1998; 25(4): S24-S26.
Hitiris N, Mohanraj R, Norrie J, Brodie MJ. Mortality in epilepsy. Epilepsy Behav 2007; 10: 363-76.
Appleton RE. Mortality in pediatric epilepsy. Arch Dis Child 2003; 88(12): 1091-4.
Berg AT, Shinnar S, Testa FM, Levy SR, Smith SN, Beckerman B. Mortality in childhood-onset epilepsy. Arch Pediatr Adolesc Med 2004; 158(12): 1147-52.
Forsgren L, Hauser WA, Olafsson E, Sander JW, Sillanpaa M, Tomson T. Mortality of epilepsy in developed countries: a review. Epilepsia 2005; 46(Suppl. 11): 18-27.
Tomson T, Beghi E, Sundqvist A, Johannessen SI. Medical risks in epilepsy: a review with focus on physical injuries, mortality, traffic accidents and their prevention. Epilepsy Res 2004; 60(1): 1-16.
Beghi E, Leone M, Solari A. Mortality in patients with a first unprovoked seizure. Epilepsia 2005; 46(Suppl. 11): 40-2.
Carpio A, Bharucha NE, Jallon P, et al. Mortality of epilepsy in developing countries. Epilepsia 2005; 46(Suppl. 11): 28-32.
Lhatoo SD, Sander JW. Cause-specific mortality in epilepsy. Epilepsia 2005; 46(Suppl 11): 36-9.
Tomson T, Walczak T, Sillanpaa M, Sander JW. Sudden unexpected death in epilepsy: a review of incidence and risk factors. Epilepsia 2005; 46(Suppl 11): 54-61.
Tomson T, Nashef L, Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol 2008; 7(11): 1021-31.
Logroscino G, Hesdorffer DC. Methodologic issues in studies of mortality following epilepsy: measures, types of studies, sources of cases, cohort effects, and competing risks. Epilepsia 2005; 46(Suppl 11): 3-7.
Tellez-Zenteno JF, Ronquillo LH, Wiebe S. Sudden unexpected death in epilepsy: evidence-based analysis of incidence and risk factors. Epilepsy Res 2005; 65(1-2): 101-15.
Tomson T. Mortality in epilepsy. J Neurol 2000; 247: 12-21.
Monte CP, Arends JB, Tan IY, Aldenkamp AP, Limburg M, de Krom MC. Sudden unexpected death in epilepsy patients: Risk factors. A systematic review. Seizure 2007; 16(1): 1-7.
So EL, Bainbridge J, Buchhalter JR, et al. Report of the American Epilepsy Society and the Epilepsy Foundation joint task force on sudden unexplained death in epilepsy. Epilepsia 2009; 50(4): 917-22.
So EL. What is known about the mechanisms underlying SUDEP? Epilepsia 2008; 49(Suppl 9): 93-8.
Severson CA, Wang W, Pieribone VA, Dohle CI, Richerson GB. Midbrain serotonergic neurons are central pH chemoreceptors. Nat Neurosci 2003; 6(11): 1139-40.
Logroscino G, Hesdorffer DC, Cascino G, et al. Mortality after a first episode of status epilepticus in the United States and Europe. Epilepsia 2005; 46(Suppl 11): 46-8.
Christensen J, Vestergaard M, Mortensen PB, Sidenius P, Agerbo E. Epilepsy and risk of suicide: a population-based casecontrol study. Lancet Neurol 2007; 6(8): 693-8.
Pompili M, Girardi P, Tatarelli R. Death from suicide versus mortality from epilepsy in the epilepsies: a meta-analysis. Epilepsy Behav 2006; 9(4): 641-8.
Nei M, Bagla R. Seizure-related injury and death. Curr Neurol Neurosci Rep 2007; 7(4): 335-41.
Faught E, Duh MS, Weiner JR, Guerin A, Cunnington MC. Nonadherence to antiepileptic drugs and increased mortality: findings from the RANSOM Study. Neurology 2008; 71(20): 1572-8.
Spencer S, Huh L. Outcomes of epilepsy surgery in adults and children. Lancet Neurol 2008; 7(6): 525-37.
So EL, Bainbridge J, Buchhalter JR, et al. Report of the American Epilepsy Society and the Epilepsy Foundation joint task force on sudden unexplained death in epilepsy. Epilepsia 2009; 50(4): 917-22.