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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2009, Number 1

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Rev Invest Clin 2009; 61 (1)

Fcγ receptors polymorphisms and systemic lupus erythematosus

Brambila-Tapia AJL, Dávalos-Rodríguez IP

Language: Spanish
References: 30
Page: 66-72
PDF size: 209.51 Kb.


ABSTRACT

The G Immunoglobulin Fc Receptors (FcγR) belong to the TNFR5 receptors family, of the immunoglobulin superfamily and are widely expressed in the immune system; their function follows in importance after the complement receptors for immunocomplexes clearance. On the other hand, the systemic lupus erythematosus (SLE) is the prototype of the autoimmune diseases mediated by immunocomplexes and several studies have shown an impaired handle of these ones in part due to dysfunction of the FcγR. Among all types of Fcγ receptors, the FcγRIIA, FcγRIIB, FcγRIIIA and FcγRIIIB have well characterized polymorphisms that produce an alteration in the receptor function. A number of studies have been done worldwide to probe an association between these polymorphism and SLE or some of its clinical features, among these the most important are two meta-analyses in which it is shown that the FcγRIIA-R131 polymorphism present a significant association with SLE susceptibility (OR: 1.3, 95%CI: 1.10-1.52), while the FcγRIIIA F176 polymorphism showed to be associated with lupic nephritis (OR: 1.47, 95%CI: 1.11-1.93, p = 0.006) but not with SLE susceptibility, the results in the rest of the polymorphisms studied are still contradictories.


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