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2013, Number 1

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Revista Cubana de Obstetricia y Ginecología 2013; 39 (1)

Function of Receptor 1 in uptaking transferrin and its relation to iron deficiency and iron gestational preeclampsia

Gómez-Gutiérrez AM, Parra-Sosa BE, Bueno-Sánchez JC

Language: Spanish
References: 39
Page: 33-42
PDF size: 94.14 Kb.


ABSTRACT

Iron deficiency gestational anemia affects 48 % of women and it is associated with deleterious effects for the mother and her fetus. For mother iron uptake, the syncytiotrophoblast expression of glycoprotein transferrin receptor 1 (TfR1) is required. In cellular trails, in animal models and in humans, iron deprivation has been associated with an increase in TfR1 transcription and expression, which has been explained as a compensatory mechanism for the fetus iron uptake. On the other hand, pregnancy alterations such as preeclampsia are expected to increase in the expression of placental TfR1; however, a reduction of it has shown. This event has been explained as a type transcriptional regulatory factor related to the hypoxia-inducible transcription. Our objective was to review evidence to support that in the reduction of TfR1 preeclampsia expression, changes in glycosylation are involved as a posttranslational modification regarding the appropriate folding, maturation and receptor export to the cell membrane. PubMed database was consulted to identify the most relevant articles. The descriptors used were iron metabolism, anemia, placenta, transferrin receiver, preeclampsia, glycosylation. A posttranscriptional regulation related to glycosylation is proposed explaining how a reduction in expression is generated, despite of the increase in RNA expression of TfR1messenger induced by hypoxia in the preeclamptic placenta.


REFERENCES

  1. Kaiser L, Allen LH, Association AD. Position of the American Dietetic Association: nutrition and lifestyle for a healthy pregnancy outcome. J Am Diet Assoc. 2008;108(3):553-61.

  2. World Health Organization. Center for Disease Control and Prevention Atlanta. Worldwide prevalence of anaemia 19932005: WHO global database on anaemia. [internet]. [consultado 18 Abr 2011 ]. Disponible en: http://whqlibdoc.who.int/publications/2008/9789241596657_eng.pdf

  3. Fonseca CZ, Heredia VP, Ocampo TP, Forero TY, Sarmiento DO, Alvarez UM, et al. Encuesta Nacional de la Situación Nutricional en Colombia 2010 ENSIN. 1ra. ed. Bogotá: Ministerio de la Protección Social, Instituto de Bienestar familiar, Instituto Nacional de Salud, Profamilia; 2011.

  4. Anderson J. Minerals. En: Mahan LK, Escott-Stump S. Krause,s Food, Nutrition, & Diet Therapy. 11th ed. Philadelphia: Saunders; 2004. p. 120-163.

  5. McCann JC, Ames BN. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr. 2007;85(4):931-45.

  6. Milman N. Prepartum anaemia: prevention and treatment. Ann Hematol. 2008;87(12):949-59.

  7. Kalaivani K. Prevalence & consequences of anaemia in pregnancy. Indian J Med Res. 2009;130(5):627-33.

  8. Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr. 2000;71(5 Suppl):1280S-4S.

  9. Rasmussen K. Is There a Causal Relationship between Iron Deficiency or Iron-Deficiency Anemia and Weight at Birth, Length of Gestation and Perinatal Mortality? J Nutr. 2001;131(2S-2):590S-601S; discussion S-3S.

  10. Lewis RM, Cleal JK, Hanson MA. Review: Placenta, evolution and lifelong health. Placenta. 2012;33 Suppl:S28-32.

  11. Little MP, Brocard P, Elliott P, Steer PJ. Hemoglobin concentration in pregnancy and perinatal mortality: a London-based cohort study. Am J Obstet Gynecol. 2005;193(1):220-6.

  12. Zhou LM, Yang WW, Hua JZ, Deng CQ, Tao X, Stoltzfus RJ. Relation of hemoglobin measured at different times in pregnancy to preterm birth and low birth weight in Shanghai, China. Am J Epidemiol. 1998;148(10):998-1006.

  13. Fuchs R, Ellinger I. Endocytic and transcytotic processes in villous syncytiotrophoblast: role in nutrient transport to the human fetus. Traffic. 2004;5(10):725-38.

  14. Huppertz B. The anatomy of the normal placenta. J Clin Pathol. 2008;61(12):1296-302.

  15. Bischof P, Irminger-Finger I. The human cytotrophoblastic cell, a mononuclear chameleon. Int J Biochem Cell Biol. 2005;37(1):1-16.

  16. Wada HG, Hass PE, Sussman HH. Transferrin receptor in human placental brush border membranes. Studies on the binding of transferrin to placental membrane vesicles and the identification of a placental brush border glycoprotein with high affinity for transferrin. J Biol Chem. 1979;254(24):12629-35.

  17. Orberger G, Geyer R, Stirm S, Tauber R. Structure of the N-linked oligosaccharides of the human transferrin receptor. Eur J Biochem. 1992;205(1):257-67.

  18. Orberger G, Fuchs H, Geyer R, Gessner R, Köttgen E, Tauber R. Structural and functional stability of the mature transferrin receptor from human placenta. Arch Biochem Biophys. 2001;386(1):79-88.

  19. Byrne SL, Leverence R, Klein JS, Giannetti AM, Smith VC, MacGillivray RT, et al. Effect of glycosylation on the function of a soluble, recombinant form of the transferrin receptor. Biochemistry. 2006;45(21):6663-73.

  20. Do SI, Enns C, Cummings RD. Human transferrin receptor contains O-linked oligosaccharides. J Biol Chem. 1990;265(1):114-25.

  21. Ohtsubo K, Marth JD. Glycosylation in cellular mechanisms of health and disease. Cell. 2006;126(5):855-67.

  22. Hunt RC, Riegler R, Davis AA. Changes in glycosylation alter the affinity of the human transferrin receptor for its ligand. J Biol Chem. 1989;264(16):9643-8.

  23. Rutledge E, Root B, Lucas J, Enns C. Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor. Blood. 1994; 83(2):580.

  24. Li YQ, Yan H, Bai B. Change in iron transporter expression in human term placenta with different maternal iron status. Eur J Obstet Gynecol Reprod Biol; 2008:48-54.

  25. Bastin J, Drakesmith H, Rees M, Sargent I, Townsend A. Localisation of proteins of iron metabolism in the human placenta and liver. Br J Haematol. 2006;134(5):532-43.

  26. McArdle HJ, Lang C, Hayes H, Gambling L. Role of the placenta in regulation of fetal iron status. Nutr Rev. 2011;69 Suppl 1:S17-22.

  27. Gambling L, Danzeisen R, Fosset C, Andersen HS, Dunford S, Srai SK, et al. Iron and copper interactions in development and the effect on pregnancy outcome. J Nutr. 2003;133(5 Suppl 1):1554S-6S.

  28. Forrellat M, Fernández N, Hernández P. Nuevos conocimientos sobre el metabolismo del hierro. [consultado 16 Mar 2011 ]. Disponible en: http://bvs.sld.cu/revistas/hih/vol21_3_05/hih03305.htm

  29. Schneider BD, Leibold EA. Effects of iron regulatory protein regulation on iron homeostasis during hypoxia. Blood. 2003;102(9):3404-11.

  30. Forrellat B M, Gautier H, Fernández N. Metabolismo del hierro. Rev Cubana Hematol Inmunol Hemoter. 2000;16(3):149-60.

  31. Gambling L, Danzeisen R, Gair S, Lea RG, Charania Z, Solanky N, et al. Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochem J. 2001;356(Pt 3):883-9.

  32. Gambling L, Andersen HS, Czopek A, Wojciak R, Krejpcio Z, McArdle HJ. Effect of timing of iron supplementation on maternal and neonatal growth and iron status of iron-deficient pregnant rats. J Physiol. 2004;561(Pt 1):195-203.

  33. Young MF, Pressman E, Foehr ML, McNanley T, Cooper E, Guillet R, et al. Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents. Placenta. 2010;31(11):1010-4.

  34. Khatun R, Wu Y, Kanenishi K, Ueno M, Tanaka S, Hata T, et al. Immunohistochemical study of transferrin receptor expression in the placenta of pre-eclamptic pregnancy. Placenta. 2003;24(8-9):870-6.

  35. Mandò C, Tabano S, Colapietro P, Pileri P, Colleoni F, Avagliano L, et al. Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas. Placenta. 2011;32(1):44-50.

  36. Wenger RH. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 2002;16(10):1151-62.

  37. Pringle KG, Kind KL, Sferruzzi-Perri AN, Thompson JG, Roberts CT. Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy. Hum Reprod Update. 2010;16(4):415-31.

  38. Bianchi L, Tacchini L, Cairo G. HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation. Nucleic Acids Res. 1999;27(21):4223-7.

  39. 39.Tacchini L, Bianchi L, Bernelli-Zazzera A, Cairo G. Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J Biol Chem. 1999;274(34):24142-6.




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